A non-cytotoxic approach to reduce ocular fibrosis following surgery in glaucoma
A non-cytotoxic approach to reduce ocular fibrosis following surgery in glaucoma
批准号:
nhmrc : 1102092
负责人:
Dr Hitesh Peshavariya
金额:
$40.26万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Glaucoma surgery often leads to scar formation and blindness. We have identified a novel protein (NADPH oxidase 4; Nox4) which promotes scar formation in the eye. Lack of Nox4 in a mouse models reduces scar formation. We have demonstrated that a ‘repurposed’ drug which is currently used to treat lung diseases can also block Nox4 in the eye. We aim to determine whether this drug can be used as a novel therapy for vision loss after glaucoma surgery.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
A non-cytotoxic approach to reduce ocular fibrosis following surgery in glaucoma
-
批准号:nhmrc : GNT1102092
-
项目类别:Project Grants
-
资助金额:$58.7万
-
财政年份:2016
-
负责人:Dr Hitesh Peshavariya
-
依托单位:
Mechanisms of cytoprotection from oxidative stress in endothelial cells
-
批准号:nhmrc : 327401
-
项目类别:NHMRC Postgraduate Scholarships
-
资助金额:$4.29万
-
财政年份:2005
-
负责人:Dr Hitesh Peshavariya
-
依托单位:
国内基金
海外基金
用识别EBV相关淋巴瘤抗原多肽的T细胞受体做转基因免疫治疗
-
批准号:81041002
-
项目类别:专项基金项目
-
资助金额:10.0万元
-
批准年份:2010
-
负责人:岑溪南
-
依托单位:
Endoglin基因修饰肿瘤/DC杂交细胞诱生靶向特异性抗人肺癌CTL疫苗的研究
-
批准号:30760248
-
项目类别:地区科学基金项目
-
资助金额:16.0万元
-
批准年份:2007
-
负责人:周源
-
依托单位: