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A non-cytotoxic approach to reduce ocular fibrosis following surgery in glaucoma

A non-cytotoxic approach to reduce ocular fibrosis following surgery in glaucoma
减少青光眼手术后眼部纤维化的非细胞毒性方法
批准号:
nhmrc : 1102092
负责人:
Dr Hitesh Peshavariya
金额:
$40.26万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31

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中文摘要
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英文摘要
Glaucoma surgery often leads to scar formation and blindness. We have identified a novel protein (NADPH oxidase 4; Nox4) which promotes scar formation in the eye. Lack of Nox4 in a mouse models reduces scar formation. We have demonstrated that a ‘repurposed’ drug which is currently used to treat lung diseases can also block Nox4 in the eye. We aim to determine whether this drug can be used as a novel therapy for vision loss after glaucoma surgery.
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A non-cytotoxic approach to reduce ocular fibrosis following surgery in glaucoma
  • 批准号:
    nhmrc : GNT1102092
  • 项目类别:
    Project Grants
  • 资助金额:
    $58.7万
  • 财政年份:
    2016
  • 负责人:
    Dr Hitesh Peshavariya
  • 依托单位:
Mechanisms of cytoprotection from oxidative stress in endothelial cells
  • 批准号:
    nhmrc : 327401
  • 项目类别:
    NHMRC Postgraduate Scholarships
  • 资助金额:
    $4.29万
  • 财政年份:
    2005
  • 负责人:
    Dr Hitesh Peshavariya
  • 依托单位:
国内基金
海外基金
用识别EBV相关淋巴瘤抗原多肽的T细胞受体做转基因免疫治疗
  • 批准号:
    81041002
  • 项目类别:
    专项基金项目
  • 资助金额:
    10.0万元
  • 批准年份:
    2010
  • 负责人:
    岑溪南
  • 依托单位:
Endoglin基因修饰肿瘤/DC杂交细胞诱生靶向特异性抗人肺癌CTL疫苗的研究
  • 批准号:
    30760248
  • 项目类别:
    地区科学基金项目
  • 资助金额:
    16.0万元
  • 批准年份:
    2007
  • 负责人:
    周源
  • 依托单位: