A non-cytotoxic approach to reduce ocular fibrosis following surgery in glaucoma

减少青光眼手术后眼部纤维化的非细胞毒性方法

• 批准号: nhmrc : 1102092
• 负责人: Dr Hitesh Peshavariya
• 金额: $ 40.26万
• 依托单位: Centre for Eye Research Australia Ltd
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/non-cytotoxic-approach-surgery-glaucoma/662585
• 关键词: non; cytotoxic; approach; reduce; ocular

Glaucoma surgery often leads to scar formation and blindness. We have identified a novel protein (NADPH oxidase 4; Nox4) which promotes scar formation in the eye. Lack of Nox4 in a mouse models reduces scar formation. We have demonstrated that a ‘repurposed’ drug which is currently used to treat lung diseases can also block Nox4 in the eye. We aim to determine whether this drug can be used as a novel therapy for vision loss after glaucoma surgery.

青光眼手术经常导致疤痕形成和失明。我们已经确定了一种新的蛋白质（NADPH氧化酶4; Nox 4），它可以促进眼睛中的瘢痕形成。在小鼠模型中缺乏Nox 4可减少瘢痕形成。我们已经证明，目前用于治疗肺部疾病的“再利用”药物也可以阻断眼睛中的Nox 4。我们的目的是确定这种药物是否可以作为青光眼手术后视力丧失的新疗法。