EVALUATION OF INTERMEDIATE ENDPOINTS AND THEIR MODULATIO

两岁的来港白母鸡被纳入一项为期两年的化学预防试验，其中鸟类被随机分配到饮食控制组或含有4-HPR的饮食组，或左炔诺孕酮的剂量与普通避孕药诺黛特相当。各种替代终点生物标志物被用来验证试验中测试的每一种卵巢癌预防剂。鸡卵巢癌的分子生物学与女性卵巢癌的分子生物学相似，这是建立鸡模型用于化学预防剂测试有效性的关键一步。

White Leghorn two-year old hens are entered into a two-year chemoprevention trial, wherein birds are randomized to diet control or diet containing 4-HPR, or Levonorgestrel at a dose comparable to the common contraceptive Nodette. A variety of surrogate endpoint biomarkers are used to validate each of the ovarian cancer preventive agents that are tested in the trial. The demonstration that the molecular biology of ovarian cancers in the fowl are similar to those seen in women is a critical step toward establishing the validity of the chicken model for testing chemopreventive agents.