EVALUATION OF INTERMEDIATE ENDPOINTS AND THEIR MODULATIO

中间端点及其调制的评估

• 批准号: 6356776
• 负责人: MARTIN LIPKIN
• 金额: $ 61.06万
• 依托单位: STRANG CANCER PREVENTION CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6356776
• 关键词: biomarker; cancer prevention; chemoprevention; chickens; drug screening /evaluation; ovary neoplasms; progestins

White Leghorn two-year old hens are entered into a two-year chemoprevention trial, wherein birds are randomized to diet control or diet containing 4-HPR, or Levonorgestrel at a dose comparable to the common contraceptive Nodette. A variety of surrogate endpoint biomarkers are used to validate each of the ovarian cancer preventive agents that are tested in the trial. The demonstration that the molecular biology of ovarian cancers in the fowl are similar to those seen in women is a critical step toward establishing the validity of the chicken model for testing chemopreventive agents.

两岁的白色来航鸡参加了一项为期两年的化学预防试验，其中鸟类被随机分成饮食对照组或含有4-HPR或左炔诺孕酮的饮食，剂量与普通避孕药诺德特相当。各种替代终点生物标记物被用于验证试验中测试的每一种卵巢癌预防药物。家禽卵巢癌的分子生物学与女性卵巢癌相似的证明，是建立用于测试化学预防药物的鸡模型有效性的关键一步。