VARIOUS CHEMOPREVENTIVE AGENTS EFFECTS

各种化学预防剂的作用

• 批准号: 6165874
• 负责人: Clinton Julian Grubbs
• 金额: --
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-30 至 2000-06-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6165874
• 关键词: aromatase; breast neoplasms; cancer prevention; carcinogenesis inhibitor; cell growth regulation; chemoprevention; disease /disorder model; drug screening /evaluation; histopathology; laboratory rat; methylnitrosourea; oxidoreductase inhibitor

The objective of this workstatement is to investigate the efficacy of a variety of potential chemopreventive agents in that MNU-induced rat mammary tumor model. This model which entails injection of MNU into 50 day old rats results in tumors with many of the same properties (histopathologic, endocrinologic, response to known therapeutic and chemopreventive agents) that are typical of the human disease. This model will e used to examine a number of potential chemopreventive agents including aromatase inhibitors, differentiating agents, specific inhibitors of prostaglandin synthesis, etc. Agents which are highly effective in these models will be further investigated with respect to their biologic and toxicologic properties and advanced into clinical testing if these initial results appear promising.

本工作说明书的目的是研究a

项目成果

Effects of acute and chronic body weight gain reductions in the evaluation of agents for efficacy in mammary cancer prevention.

急性和慢性体重增加减少对评估药物预防乳腺癌功效的影响。

• DOI: 10.3892/or.8.2.373
• 发表时间: 2001
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Rodríguez-Burford,C;Lubet,RA;Steele,VE;Eto,I;Bandy,M;Juliana,MM;Weiss,HL;Grizzle,WE;Kelloff,GJ;Grubbs,CJ
• 通讯作者: Grubbs,CJ

Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology.

化学预防剂治疗导致体重增加减少对乳腺形态的影响。

• DOI: 10.1207/s15327914nc431_8
• 发表时间: 2002
• 期刊: Nutrition and cancer
• 作者: Rodriguez-Burford,Cristina;Steele,VernonE;Anderson,AmyS;Stockard,CecilR;Weiss,HeidiL;Eto,Isao;Johanning,GaryL;Grizzle,WilliamE;Grubbs,ClintonJ
• 通讯作者: Grubbs,ClintonJ