DEVELOPMENT OF PEPTIDERGIC PROJECTIONS FROM ARCUATE NUCLEUS OF HYPOTHALAMUS

下丘脑弓状核肽能投射的发育

• 批准号: 6312863
• 负责人: RICHARD B SIMERLY
• 金额: $ 5.84万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6312863
• 关键词: Chordata; Mammalia; animal tissue; biotechnology; endocrine gland /system; growth /development; hormones; inborn metabolism disorder; infant mortality; low birth weight infant human; mother /infant health care; respiratory system

The bombesin-like peptides comprise a large family of peptides originally characterized in amphibians, then later found to be widely distributed in mammals. CNS administration of bombesin to rats has potent effects on appetite, body temperature, grooming, heart rate, and GI function. Two mammalian bombesin-like peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) have been characterized to date. At present, three mammalian bombesin-like peptide receptors have been characterized; the GRP receptor (also known as the bombesin BB2 receptor), the NMB receptor (also known as the BB1 receptor) and a third, orphan receptor whose ligand is unknown, designated the BRS-3 receptor or BB3 receptor. These known receptors cannot, however, explain all of bombesin=s CNS effects, particularly bombesin=s effects on body temperature and grooming. This suggests that other bombesin receptor subtypes remain to be characterized. Our laboratory has now characterized two new recep tors related to the bombesin receptors. These receptors are very highly expressed in the CNS. These receptors have been designated GPCR-CNS1 and GPCR-CNS2. In the CNS, expression is primarily found in glia. Preliminary results suggest that each receptor is preferentially localized in different glial subtypes. Unlike the GRP receptor, these receptors are not present in fetal monkey lung. FUNDING SOURCE NIH NS35580 PUBLICATIONS Leng N, Gu GB, Simerly RB, Spindel ER. Molecular cloning and characterization of GPCR/CNS2, a novel G-protein coupled receptor which is highly expressed in the central nervous system. Soc Neurosci Abstr 24:1091, 1998 (abstract 432.11).

炸弹蛋白样肽包括一个大家族的肽