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CONFOCAL RAMAN MICROSPECTROSCOPY FOR BIOLOGICAL MICROSTRUCTURE ANALYSIS

CONFOCAL RAMAN MICROSPECTROSCOPY FOR BIOLOGICAL MICROSTRUCTURE ANALYSIS
用于生物微观结构分析的共焦拉曼显微镜
批准号：
6314197
负责人：
GEURT DEINUM
金额：
$1.38万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-06-01 至 2001-05-31
来源：
https://reporter.nih.gov/project-details/6314197
关键词：
bioimaging /biomedical imaging biomedical equipment development biomedical resource cardiovascular system clinical research human tissue microscopy spectrometry technology /technique women's health

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英文摘要
We have augmented our bulk near IR Raman spectroscopy with confocal microscope illumination and collection of Raman signals from thin sections with very high spatial resolution on the order of 1 micron. The novel optical design enables switching between bulk and microscope spectroscopic studies fairly easy. We have used this confocal Raman microscope system for collecting spectra of a variety of morphological structures in artery, breast, and brain tissues. The ultimate goal is to use these information for the understanding of microscopic and morphological basis of Raman signals from bulk tissues and correlate with histopathology.
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