FUNCTIONAL BIOSYNTHETIC ROLES OF POLYKETIDE SYNTHASES, CYCLASES & KETOREDUCTASES

聚酮化合物合成酶、环化酶的生物合成功能

基本信息

  • 批准号:
    6309115
  • 负责人:
  • 金额:
    $ 0.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-04-15 至 2005-02-28
  • 项目状态:
    已结题

项目摘要

Iterative type II polyketide synthases (PKSs) have been determined to produce polyketide chains of variable but defined length from a specific starter unit and a certain number of extender units. They also specify the initial regiospecific folding and cyclization pattern of nascent polyketides either through the action of a cyclase (CYC) subunit or through the combined influence of site-specific ketoreductase (KR) and CYC subunits. Additional cyclases and other modifiactions may be necessary to yield the various known members of the class of linear aromatic compoinds, several of which have proven medical significance. However, it was not known whether angular aromatic polyketides would assemble using the same principles as described for PKSs that yield linear aromatic polyketides. Genes for angular polyketides including a cyclase gene thought to be responsible for folding of the polyketide chain to produce angular polyketide intermediates have been cloned and expressed in host strains S. lividans and S. glaucescens. We are now in the process of characterizing several polyketide intermediates produced in these host strains to further define the iterative functions of the PKSs, Cnd KRs in generating angular aromatic polyketide intermediates.
迭代型II型聚酮合成酶(PKSs)已被确定

项目成果

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会议论文数量(0)
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CHARLES R HUTCHINSON其他文献

CHARLES R HUTCHINSON的其他文献

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{{ truncateString('CHARLES R HUTCHINSON', 18)}}的其他基金

Leptomycin B Development for Cancer Therapy
用于癌症治疗的 Leptomycin B 开发
  • 批准号:
    6788646
  • 财政年份:
    2004
  • 资助金额:
    $ 0.75万
  • 项目类别:
Novel Geldanamycin Analogs as Anti-Tumor Agents
作为抗肿瘤剂的新型格尔德霉素类似物
  • 批准号:
    6738936
  • 财政年份:
    2004
  • 资助金额:
    $ 0.75万
  • 项目类别:
Laulimalide Production Genes
劳利马内酯生产基因
  • 批准号:
    6584382
  • 财政年份:
    2003
  • 资助金额:
    $ 0.75万
  • 项目类别:
Novel Geldanamycin Analogs as Anti-tumor Agents
作为抗肿瘤剂的新型格尔德霉素类似物
  • 批准号:
    6484983
  • 财政年份:
    2002
  • 资助金额:
    $ 0.75万
  • 项目类别:
Discodermolide Biosynthesis Genes
Discodermolide 生物合成基因
  • 批准号:
    6549229
  • 财政年份:
    2002
  • 资助金额:
    $ 0.75万
  • 项目类别:
New Ketolide Antibacterial Drugs
新型酮内酯类抗菌药
  • 批准号:
    6645823
  • 财政年份:
    2002
  • 资助金额:
    $ 0.75万
  • 项目类别:
New Ketolide Antibacterial Drugs
新型酮内酯类抗菌药
  • 批准号:
    6906470
  • 财政年份:
    2002
  • 资助金额:
    $ 0.75万
  • 项目类别:
New Ketolide Antibacterial Drugs
新型酮内酯类抗菌药
  • 批准号:
    6443213
  • 财政年份:
    2002
  • 资助金额:
    $ 0.75万
  • 项目类别:
DM1-Monoclonal Antibody Conjugates
DM1-单克隆抗体偶联物
  • 批准号:
    6549145
  • 财政年份:
    2002
  • 资助金额:
    $ 0.75万
  • 项目类别:
New Ketolide Antibacterial Drugs
新型酮内酯类抗菌药
  • 批准号:
    6742436
  • 财政年份:
    2002
  • 资助金额:
    $ 0.75万
  • 项目类别:
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