FUNCTIONAL BIOSYNTHETIC ROLES OF POLYKETIDE SYNTHASES, CYCLASES & KETOREDUCTASES
聚酮化合物合成酶、环化酶的生物合成功能
基本信息
- 批准号:6309115
- 负责人:
- 金额:$ 0.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-04-15 至 2005-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Iterative type II polyketide synthases (PKSs) have been determined
to produce polyketide chains of variable but defined length from a
specific starter unit and a certain number of extender units. They
also specify the initial regiospecific folding and cyclization pattern
of nascent polyketides either through the action of a cyclase (CYC)
subunit or through the combined influence of site-specific
ketoreductase (KR) and CYC subunits. Additional cyclases and other
modifiactions may be necessary to yield the various known members of
the class of linear aromatic compoinds, several of which have proven
medical significance. However, it was not known whether angular
aromatic polyketides would assemble using the same principles as
described for PKSs that yield linear aromatic polyketides. Genes for
angular polyketides including a cyclase gene thought to be responsible
for folding of the polyketide chain to produce angular polyketide
intermediates have been cloned and expressed in host strains S.
lividans and S. glaucescens. We are now in the process of
characterizing several polyketide intermediates produced in these host
strains to further define the iterative functions of the PKSs, Cnd KRs
in generating angular aromatic polyketide intermediates.
迭代型II型聚酮合成酶(PKSs)已被确定
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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CHARLES R HUTCHINSON其他文献
CHARLES R HUTCHINSON的其他文献
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{{ truncateString('CHARLES R HUTCHINSON', 18)}}的其他基金
Leptomycin B Development for Cancer Therapy
用于癌症治疗的 Leptomycin B 开发
- 批准号:
6788646 - 财政年份:2004
- 资助金额:
$ 0.75万 - 项目类别:
Novel Geldanamycin Analogs as Anti-Tumor Agents
作为抗肿瘤剂的新型格尔德霉素类似物
- 批准号:
6738936 - 财政年份:2004
- 资助金额:
$ 0.75万 - 项目类别:
Novel Geldanamycin Analogs as Anti-tumor Agents
作为抗肿瘤剂的新型格尔德霉素类似物
- 批准号:
6484983 - 财政年份:2002
- 资助金额:
$ 0.75万 - 项目类别: