A novel G-Protein Coupled Receptor-based memory process mediating the cognitive control of action.

一种新颖的基于 G 蛋白偶联受体的记忆过程介导行动的认知控制。

• 批准号: nhmrc : GNT1166008
• 金额: $ 52.78万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-g-protein-control-action/1379426
• 关键词: novel; Protein; Coupled; Receptor; based

Deficits in the cognitive control of action are observed in a number of neurodegenerative and psychiatric conditions. We have found evidence of a novel neuronal mechanism in the striatum that mediates a key memory process associated with cognitive control that we will explore using manipulations of the striatum and of its afferents in the amygdala and midline thalamus and that, if successful, we provide novel targets for treatment of what is currently a much neglected condition.

在许多神经退行性疾病和精神疾病中都观察到行动的认知控制缺陷。我们已经发现了纹状体中一种新的神经元机制的证据，该机制介导了与认知控制相关的关键记忆过程，我们将通过对纹状体及其杏仁核和丘脑中线的传入事件的操纵来探索，如果成功，我们将为治疗目前被忽视的疾病提供新的靶点。