SYNTHESIS AND BIOLOGICAL EVALUATION/ANTIHIV NUCLEOSIDES

描述：（改编自申请人的摘要）： 在艾滋病毒感染的治疗方面，有一些 艾滋病化疗中尚未解决的问题，包括病毒耐药性， 病毒储库、挽救治疗和潜在的病毒消除。 为了解决所有这些问题，未来迫切需要 将是发现更有效和更有选择性的新的抗艾滋病毒疗法 与批准的药物有不同的耐药性这项建议 是在以下领域正在进行的药物发现工作的延续： 格鲁吉亚大学和埃默里大学的抗病毒核苷 大学/VA医疗中心。研究人员建议探索 化学和病毒学的以下类别的主要L-核苷： (1)氧杂硒环戊烷核苷;（2）氟化L-D4 N;（3）2-取代 L-碳环核苷;（4）L-apionucleosides;（5）L-oxetanocin 类似物;（6）环丁烷碳环L-核苷;（7）构象 限制性内切环丙基核苷;（8）高- 环丙基碳环核苷。

DESCRIPTION: (Adapted from Applicant's Abstract): Despite significant advances in the treatment of HIV infection, there are a number of unresolved issues in AIDS chemotherapy, including viral resistance, viral reservoir, salvage therapy and potential elimination of the virus. In order to solve all these problems, the critical need in the future will be the discovery of more potent and selective new anti-HIV regimens with different patterns of resistance than approved drugs. This proposal is a continuation of ongoing drug discovery efforts in the area of antiviral nucleosides at the University of Georgia and the Emory University/VA Medical Center. The investigators propose to explore the chemistry and virology of the following classes of mainly L-nucleosides: (1) oxaselenolane nucleosides; (2) fluorinated L-D4N; (3) 2-substituted L-carbocyclic nucleosides; (4) L-apionucleosides; (5) L-oxetanocin analogs; (6) cyclobutane carbocyclic L-nucleosides; (7) conformationally restricted endo-cyclopropropylnucleosides; (8) homo- cyclopropylcarbocyclic nucleosides.