A novel mechanism for improving β-cell function and survival in diabetes.

改善糖尿病β细胞功能和生存的新机制。

• 批准号: nhmrc : GNT1158242
• 金额: $ 67.25万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-mechanism-improving-survival-diabetes/1379021
• 关键词: novel; mechanism; improving; cell; function

One of the key therapy options for type 1 diabetes is islet transplantation, however, several obstacles remain to be addressed. It is recognised that any potential therapies should at least associate with enhanced β-cell function during islet transplantation. Our studies in human islets have shown that inhibition of a novel receptor signaling could be the key for such improvements. We will now extend this work by a detailed exploration of the mechanisms that regulate these functions.

1型糖尿病的关键治疗选择之一是胰岛移植，然而，仍有一些障碍有待解决。人们认识到，任何潜在的疗法都应至少与胰岛移植期间增强的β细胞功能相关。我们在人类胰岛中的研究表明，抑制一种新的受体信号可能是这种改善的关键。我们现在将通过详细探索调节这些功能的机制来扩展这项工作。