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Linear Geiger Mode Detector Technology for Time Resolved Spectral Measurements

用于时间分辨光谱测量的线性盖革模式检测器技术

基本信息

批准号：
ST/N000145/1
负责人：
Jo Shien Ng
金额：
$ 18.79万
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=ST%2FN000145%2F1
关键词：
Linear Geiger Mode Detector Technology

项目摘要

The primary objective of this project is to develop a new class of detection system for cost effective time-resolved photon counting spectral measurement, initially aimed at time-resolved Raman spectroscopy (TRRS). TRRS is an established method to remove the delayed fluorescence signal from the prompt Raman photons, particularly for organic samples where the fluorescence signal is often much larger. Though very powerful as a sample analysis technique, TRRS has had limited uptake due to cost and complexity. Currently available TRRS systems separate the Raman and fluorescence signals by using either a gated Intensified CCD, or by using fast optical gating technology. Both approaches are complex, expensive and restricted to laboratory environments. This proposal aims to produce a new, smaller, cheaper class of detection system for TRRS and other time-resolved spectral measurements by integrating a SPAD linear array developed by the University of Sheffield with the fast readout electronics developed by the University of Leicester. Instead of gating, this system will provide the necessary time differentiation of Raman and fluorescence signals by photon time stamping.Such an instrument is expected to open up new commercial applications in to fields ranging from security applications such as identification of counterfeit materials and pharmaceutical quality control, to biological applications including protein manufacture and potentially identification of cancer markers. A cost effective time-resolved Raman instrument would be disruptive technology with beneficiaries ranging from the project partners through commercial profit and licensing, suppliers of key components including commercial detector and high rep rate lasers from UK and European companies. Potential end-user beneficiaries include drug companies and their customers, the security services and general public through improved detection of hazardous and illegal materials, and public well-being through possible advances in cancer detection.The detector system is also potentially game-changing for a number of other commercial applications. These include: LIDAR for 3D imaging and environmental monitoring; fluorescence lifetime imaging and related technologies for biological research, drug discovery and clinical diagnostics; and trace gas analysis using cavity enhanced absorption spectroscopy for pollution monitoring and medical diagnostics.The project work is based on previous STFC-funded research into detectors and electronics at the Universities of Leicester and Sheffield and at CERN.The Department of Electronic & Electrical Engineering at the University of Sheffield has been carrying out research into SPADs for over 15 years. Recent knowledge exchange activities include IR APD linear array with LIDAR Technology, X-ray APDs with University of Leicester, photodiodes/APDs for radiation thermometry with LAND Instrument International Ltd, and IR APD with Lasertel.The University of Leicester and commercial partner, IS-Instruments, were recently awarded a TSB-funded "Emerging Imaging Technologies" feasibility study for preliminary investigation of this new technique for TRRS. This new project will move the technology from proof of concept to a commercial prototype for TRRS which will allow IS-Instruments to commercialise a new suite of spectrometer systems capable of separating signals in time, generating the potential for cost effective, hand-held TRRS spectrometer.Previous STFC support has funded the PI, Lapington, to develop very high time resolution pixellated microchannel plate photomultiplier systems for commercial applications in the life science arena, based on a modular, multichannel high speed electronics with picosecond event timing resolution developed in collaboration with CERN. The electronics utilise two very high speed CERN-designed ASICs developed for the LHC-ALICE experiment in a modular design allowing systems with up to 1024 channels.

该项目的主要目标是开发一种新的检测系统，用于具有成本效益的时间分辨光子计数光谱测量，最初针对时间分辨拉曼光谱（TRRS）。TRRS是一种从即时拉曼光子中去除延迟荧光信号的既定方法，特别是对于荧光信号通常大得多的有机样品。虽然TRRS作为一种样品分析技术非常强大，但由于成本和复杂性，其应用有限。目前可用的TRRS系统通过使用门控增强CCD或通过使用快速光学门控技术来分离拉曼和荧光信号。这两种方法都是复杂的，昂贵的，并限于实验室环境。该提案旨在通过将谢菲尔德大学开发的SPAD线性阵列与莱斯特大学开发的快速读出电子学相结合，为TRRS和其他时间分辨光谱测量产生一种新的、更小、更便宜的检测系统。代替选通，该系统将通过光子时间戳提供拉曼和荧光信号的必要时间微分。这种仪器有望开辟新的商业应用领域，从安全应用，如识别假冒材料和药物质量控制，到生物应用，包括蛋白质制造和潜在的癌症标志物识别。具有成本效益的时间分辨拉曼仪器将是颠覆性技术，受益者包括项目合作伙伴、商业利润和许可证、关键部件供应商，包括来自英国和欧洲公司的商业探测器和高重复率激光器。潜在的最终用户受益者包括制药公司及其客户、安全部门和公众（通过改进对危险和非法材料的检测）以及公众福祉（通过癌症检测的可能进展）。其中包括：用于3D成像和环境监测的激光雷达;用于生物研究、药物发现和临床诊断的荧光寿命成像和相关技术;利用腔增强吸收光谱法进行污染监测和医疗诊断的痕量气体分析。该项目工作是基于莱斯特大学和谢菲尔德大学以及欧洲核子研究中心以前由STFC资助的探测器和电子学研究。电子和电子学系谢菲尔德大学的电气工程已经对SPAD进行了超过15年的研究。最近的知识交流活动包括使用LIDAR技术的IR APD线性阵列、与莱斯特大学合作的X射线APD、与LAND Instrument International Ltd合作的用于辐射测温的光电二极管/APD以及与Lasertel合作的IR APD。莱斯特大学及其商业合作伙伴IS-Instruments最近获得了TSB资助的“新兴成像技术”可行性研究，以初步研究TRRS的这种新技术。这个新项目将把技术从概念验证转移到TRRS的商业原型，这将使IS仪器公司能够将一套新的光谱仪系统商业化，该系统能够及时分离信号，从而产生具有成本效益的手持式TRRS光谱仪的潜力。为了开发用于生命科学竞技场中的商业应用的非常高的时间分辨率的像素化微通道板光电倍增管系统，基于模块化，与欧洲核子研究中心合作开发的具有皮秒事件定时分辨率的多通道高速电子设备。电子设备采用两个非常高速的欧洲核子研究中心设计的ASIC开发的LHC-ALICE实验在一个模块化的设计，允许系统与多达1024个通道。