SYNTHESIS & ANTIMYCOBACTERIAL ACTIVITY OF NOVEL SCHIFF BASES

合成

• 批准号: 6345220
• 负责人: MICHAEL J HEARN
• 金额: $ 0.06万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6345220
• 关键词: bioengineering /biomedical engineering; biological products; biomaterials; biomedical equipment development; biomedical resource; environmental toxicology; eye; proteins; spectrometry; structural biology; technology /technique

Utilization of dyes particularly in conjunction with organic polymers, is of interest in a number of contexts, including solar photochemistry, the operation of dye lasers, and the functionalization of biopolymers and proteins. In another context, investigation of biopolymer-bound dyes is important in understanding the fate of commercial dyestuffs as environmental pollutants in aquatic media. Arrays of chromophores in polymers are also of potential use in the development of photonic devices (e.g., molecular electronics). Novel effects induced by binding organic dyes to amphiphilic or water-soluble polymers (including peptides and proteins) are of particular interest to our group. Flash illumination, fluorescence, circular dichroism, and molecular modeling techniques are employed in the investigation of the properties of polymer-bound dye systems. Synthetic work is directed to judicious placement of chromophores and electron transfer groups in peptides or proteins. Investigations include the effect of polymer conformation (e.g., the presence of a-helices in peptides) in controlling photochemical behavior fordye-biopolymer assemblies. These studies are directed to a number of objectives, including the advance of theories dealing with long-range electron transfer, the development of new dye-polymer (drug-carrier) conjugates, and characterization of the photochemistry of dyestuffs bound to biopolymers such as humic acids in natural aquatic media. In this project, a series of peptides arebeing synthesized with covalently attached dye moieties attached to the N-terminus. These arethen allowed to self-assemble into structures that incorporate defined features (e.g., beta sheets and helices) that place the dyes in fixed spatial relationships to one another. The efficiency of electron transfers within the structures are then followed using various physical techniques.

染料的利用，特别是与有机染料结合使用 聚合物，在包括太阳能在内的许多环境中都很有意义 光化学、染料激光的操作和功能化 生物聚合物和蛋白质。在另一个背景下，调查 生物聚合物结合的染料对于理解生物聚合物的命运很重要 商品染料作为水介质中的环境污染物。 聚合物中的发色团阵列也有潜在的用途 发展光子器件(如分子电子学)。小说 有机染料与两亲性染料结合的影响 水溶性聚合物(包括多肽和蛋白质)是 对我们集团特别感兴趣。闪光灯照明，荧光， 圆二色谱和分子模拟技术被应用于 聚合物结合染料体系性质的研究。 合成工作的目的是明智地放置发色团和 多肽或蛋白质中的电子转移基团。调查 包括聚合物构象的影响(例如，存在 多肽中的A-螺旋)控制光化学行为 用于染料-生物聚合物组件。这些研究针对的是一些 目标的发展，包括关于 远程电子转移，新型染料聚合物的发展 (药物-载体)结合物及其光化学表征 与生物聚合物结合的染料，如天然腐植酸 水上媒体。在这个项目中，一系列的多肽被 用共价连接的染料部分连接到 N-末端。然后，它们被允许自组装成结构 包含定义的特征(例如，测试片和螺旋) 将染料放置在彼此固定的空间关系中。这个 然后，结构内的电子转移效率 随后使用了各种物理技术。