SYNTHESIS & ANTIMYCOBACTERIAL ACTIVITY OF NOVEL SCHIFF BASES

合成

• 批准号: 6478944
• 负责人: MICHAEL J HEARN
• 金额: $ 5.36万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6478944
• 关键词: bioengineering /biomedical engineering; biological products; biomaterials; biomedical equipment development; biomedical resource; environmental toxicology; eye; proteins; spectrometry; structural biology; technology /technique

Utilization of dyes particularly in conjunction with organic polymers, is of interest in a number of contexts, including solar photochemistry, the operation of dye lasers, and the functionalization of biopolymers and proteins. In another context, investigation of biopolymer-bound dyes is important in understanding the fate of commercial dyestuffs as environmental pollutants in aquatic media. Arrays of chromophores in polymers are also of potential use in the development of photonic devices (e.g., molecular electronics). Novel effects induced by binding organic dyes to amphiphilic or water-soluble polymers (including peptides and proteins) are of particular interest to our group. Flash illumination, fluorescence, circular dichroism, and molecular modeling techniques are employed in the investigation of the properties of polymer-bound dye systems. Synthetic work is directed to judicious placement of chromophores and electron transfer groups in peptides or proteins. Investigations include the effect of polymer conformation (e.g., the presence of a-helices in peptides) in controlling photochemical behavior fordye-biopolymer assemblies. These studies are directed to a number of objectives, including the advance of theories dealing with long-range electron transfer, the development of new dye-polymer (drug-carrier) conjugates, and characterization of the photochemistry of dyestuffs bound to biopolymers such as humic acids in natural aquatic media. In this project, a series of peptides arebeing synthesized with covalently attached dye moieties attached to the N-terminus. These arethen allowed to self-assemble into structures that incorporate defined features (e.g., beta sheets and helices) that place the dyes in fixed spatial relationships to one another. The efficiency of electron transfers within the structures are then followed using various physical techniques.

染料的利用，特别是与有机染料结合使用 聚合物，在许多情况下，包括太阳能， 光化学，染料激光器的操作，和功能化 生物聚合物和蛋白质。 另一方面，调查 生物聚合物结合的染料是重要的，在了解的命运， 作为环境污染物的商业染料在水生介质中。 聚合物中的发色团阵列也具有潜在的用途， 光子器件的发展（例如，分子电子学）。 小说 通过将有机染料结合到两亲性或 水溶性聚合物（包括肽和蛋白质）是 对我们集团特别感兴趣。 闪光灯，荧光灯， 圆二色性和分子模拟技术， 聚合物结合染料系统性质的研究。 合成工作是针对发色团的明智的位置， 肽或蛋白质中的电子转移基团。 调查 包括聚合物构象的影响（例如，的存在 肽中的α-螺旋）在控制光化学行为中的作用 Fordye-生物聚合物组装体。 这些研究针对的是一些 目标，包括处理 远程电子转移，新型染料聚合物的开发 （药物-载体）缀合物，以及光化学的表征 染料结合到生物聚合物，如天然的腐殖酸， 水生媒介 在这个项目中， 用共价连接的染料部分合成， N端 然后让它们自我组装成结构 其结合了限定的特征（例如，β折叠和螺旋）， 将染料以彼此固定的空间关系放置。 的 结构内电子转移的效率， 使用各种物理技术。