SYNTHESIS & ANTIMYCOBACTERIAL ACTIVITY OF NOVEL SCHIFF BASES

合成

• 批准号: 6478944
• 负责人: MICHAEL J HEARN
• 金额: $ 5.36万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6478944
• 关键词: bioengineering /biomedical engineering; biological products; biomaterials; biomedical equipment development; biomedical resource; environmental toxicology; eye; proteins; spectrometry; structural biology; technology /technique

Utilization of dyes particularly in conjunction with organic polymers, is of interest in a number of contexts, including solar photochemistry, the operation of dye lasers, and the functionalization of biopolymers and proteins. In another context, investigation of biopolymer-bound dyes is important in understanding the fate of commercial dyestuffs as environmental pollutants in aquatic media. Arrays of chromophores in polymers are also of potential use in the development of photonic devices (e.g., molecular electronics). Novel effects induced by binding organic dyes to amphiphilic or water-soluble polymers (including peptides and proteins) are of particular interest to our group. Flash illumination, fluorescence, circular dichroism, and molecular modeling techniques are employed in the investigation of the properties of polymer-bound dye systems. Synthetic work is directed to judicious placement of chromophores and electron transfer groups in peptides or proteins. Investigations include the effect of polymer conformation (e.g., the presence of a-helices in peptides) in controlling photochemical behavior fordye-biopolymer assemblies. These studies are directed to a number of objectives, including the advance of theories dealing with long-range electron transfer, the development of new dye-polymer (drug-carrier) conjugates, and characterization of the photochemistry of dyestuffs bound to biopolymers such as humic acids in natural aquatic media. In this project, a series of peptides arebeing synthesized with covalently attached dye moieties attached to the N-terminus. These arethen allowed to self-assemble into structures that incorporate defined features (e.g., beta sheets and helices) that place the dyes in fixed spatial relationships to one another. The efficiency of electron transfers within the structures are then followed using various physical techniques.

染料的利用，特别是与有机的结合 聚合物在包括太阳能在内的许多情况下都感兴趣 光化学，染料激光器的操作和功能化 生物聚合物和蛋白质。 在另一种情况下，调查 生物聚合物结合的染料对于理解命运很重要 商业染料作为水生媒体中的环境污染物。 聚合物中发色团阵列也有潜在的用途 光子设备的开发（例如，分子电子）。 小说 结合有机染料与两亲性或 水溶性聚合物（包括肽和蛋白质）是 我们小组特别感兴趣。 闪光照明，荧光， 圆二色性和分子建模技术用于 对聚合物结合染料系统的性质的研究。 合成工作是针对发色团的明智放置 肽或蛋白质中的电子转移组。 调查 包括聚合物构象的效果（例如，存在 肽中的A螺旋）控制光化学行为 Fordye-Biopolymer组件。 这些研究针对一个数字 目标，包括处理理论的进步 远程电子转移，新的染料聚合物的发展 （毒品载体）缀合物和光化学的表征 与生物聚合物（例如天然中的腐殖酸）结合的染料 水生媒体。 在这个项目中，一系列肽正在 与附着的共同连接的染料部分合成 N末端。 这些芳香允许自组装成结构 结合了定义的功能（例如，β床单和螺旋） 将染料置于固定的空间关系中。 这 然后是在结构内的电子传输效率 随后使用各种物理技术。