THE RENAL-SPECIFIC EXPRESSION OF ACE

ACE 的肾脏特异性表达

基本信息

  • 批准号:
    6260284
  • 负责人:
  • 金额:
    $ 17.71万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-08-01 至 2005-07-31
  • 项目状态:
    已结题

项目摘要

The renin-angiotensin system is very important in the physiologic control of blood pressure and fluid balance. That said, it is also important to realize that the physiologic actions of the renin-angiotensin system are more complex than simple blood pressure control, as evidenced by the phenotype of knockout mice that lack a functional renin-angiotensin system. Our group has created mice that lack ACE. These animals have very low systolic blood pressures and are unable to effectively concentrate urine. However, what was most dramatic and unexpected was that the mice have a marked under-development of the renal medulla. We hypothesize that part of the pathophysiology of the renal phenotype is due to the lack of the local generation of angiotensin II within the kidney. This application proposes experiments to study the renal phenotype in ACE knockout mice. Our approach will be to create new strains of genetically-altered mice expressing ACE activity in selected portions of the renal nephron. These studies are designed to discriminate between angiotensin II as a local factor necessary for renal development and function, and other pathophysiologic mechanisms that may be responsible for the renal phenotype of these animals. We also describe a second line of ACE knockout mice that lacks the tissue bound form of this enzyme. The phenotype of these animals suggests that it is expression of ACE within tissues, as opposed to plasma ACE activity, that is responsible for regulating blood pressure. Using homologous recombination to create novel strains of genetically altered mice, we will examine precisely which tissues are most responsible for blood pressure control.
肾素-血管紧张素系统在人体的生理活动中起着非常重要的作用

项目成果

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KENNETH E BERNSTEIN其他文献

KENNETH E BERNSTEIN的其他文献

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{{ truncateString('KENNETH E BERNSTEIN', 18)}}的其他基金

ACE and myeloid cell metabolism
ACE 和骨髓细胞代谢
  • 批准号:
    10440789
  • 财政年份:
    2022
  • 资助金额:
    $ 17.71万
  • 项目类别:
ACE and myeloid cell metabolism
ACE 和骨髓细胞代谢
  • 批准号:
    10570941
  • 财政年份:
    2022
  • 资助金额:
    $ 17.71万
  • 项目类别:
Supplemental Grant: Increased neutrophil function in Alzheimer's disease
补充补助金:阿尔茨海默病中中性粒细胞功能增强
  • 批准号:
    10284911
  • 财政年份:
    2021
  • 资助金额:
    $ 17.71万
  • 项目类别:
Immune effects of ACE over-expression in neutrophils
中性粒细胞中 ACE 过度表达的免疫效应
  • 批准号:
    10176383
  • 财政年份:
    2018
  • 资助金额:
    $ 17.71万
  • 项目类别:
The role of angiotensin-converting enzyme in renal inflammation, kidney injury and sodium retention during diabetic nephropathy
血管紧张素转换酶在糖尿病肾病肾脏炎症、肾损伤和钠潴留中的作用
  • 批准号:
    10188616
  • 财政年份:
    2018
  • 资助金额:
    $ 17.71万
  • 项目类别:
THE ROLE OF ACE IN INFLAMMATION AND HYPERTENSION
ACE 在炎症和高血压中的作用
  • 批准号:
    9978627
  • 财政年份:
    2016
  • 资助金额:
    $ 17.71万
  • 项目类别:
Carboxypeptidase ACE and MHC Class I Presentation
羧肽酶 ACE 和 MHC I 类介绍
  • 批准号:
    8969984
  • 财政年份:
    2015
  • 资助金额:
    $ 17.71万
  • 项目类别:
THE RENAL-SPECIFIC EXPRESSION OF ACE
ACE 的肾脏特异性表达
  • 批准号:
    6523797
  • 财政年份:
    2001
  • 资助金额:
    $ 17.71万
  • 项目类别:
THE RENAL-SPECIFIC EXPRESSION OF ACE
ACE 的肾脏特异性表达
  • 批准号:
    6783436
  • 财政年份:
    2001
  • 资助金额:
    $ 17.71万
  • 项目类别:
THE RENAL-SPECIFIC EXPRESSION OF ACE
ACE 的肾脏特异性表达
  • 批准号:
    6605807
  • 财政年份:
    2001
  • 资助金额:
    $ 17.71万
  • 项目类别:

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