PATHOBIOLOGY OF MUCOSAL/EPITHELIAL DISEASE

该申请是为了建立一个新的机构NRSA，以支持最初两名到随后五名医学博士和博士后研究员的培训。虽然这是一个新项目，但一些培训教员在过去的培训中一直高度互动，而且在过去十年中，整个教员在培训现在担任学术或研究职务的个人方面非常成功。例如，在过去五年内离开培训计划的受训者显示出对研究的持续参与（大约70%的人将超过50%的努力投入到研究中）。该计划的主要目标是在粘膜疾病的病理生理学问题导向研究方面提供多学科培训，特别是极化上皮和消化道疾病。培训师资队伍由20名研究人员组成，他们拥有与该研究领域相关的独立、资助的研究项目。该学院提供现代分子、免疫学和细胞生物学方法的专业知识，用于研究疾病的病理生理学。特别强调上皮生物学和免疫学，因为它涉及到上皮生物学和免疫学，因为它涉及到消化道等部位的上皮生物学。培训计划的结构旨在促进参与教师之间的互动，并为受训者提供访问所有实验室及其大量资源的机会。学员从全国的研究生和临床项目中挑选，重点是确定代表性不足的少数民族。培训计划的主要组成部分是由受训者在他们选择的实验室进行独立研究。通过参加研究会议、期刊俱乐部和正式研讨会以及参加主要由该培训计划的教师提供的课程（即培训计划的教师在埃默里大学医学院的研究生教育计划中高度互动），培训经验进一步增强。

This application is for a new institutional NRSA to support the training of initially two and subsequently five M.D. and Ph.D. Postdoctoral Fellows. Although a new program several of the training faculty have been highly interactive in training such individuals in the past and faculty as a whole has been highly successful in training individuals over the last ten years who now hold academic or research appointments. For example trainees who have left the program of training within the last five years show significant continuing involvement in research (approximately 70% have greater than 50% effort devoted to research). The broad objective of this program is to provide multi-disciplinary training in problem oriented research on the pathophysiology of mucosal disease with special reference to polarized epithelial and alimentary tract disorders. The training faculty consists of twenty investigators with independent, funded research programs related to this area of study. The faculty provides expertise in modern molecular, immunologic and cell biologic approaches for studying pathophysiology of disease. There exists particular emphasis on epithelial biology and immunology as it relates to epithelial biology and immunology as it relates to epithelial biology at sites such as the alimentary tract. The structure of the training program is designed to promote interactions among participating faculty and to provide trainees access to all of the laboratories and their considerable resources. Trainees are selected from graduate and clinical programs nationwide with an emphasis on identifying under-represented minorities. The major component of the training program is independent research carried out by trainees in their laboratories of choice. The training experience is further enhanced by attendance at research conferences, journal clubs and formal seminars as well as attendance in coursework largely provided by the faculty of this training program (i.e. the faculty of the training program are highly interactive in the graduate education program at Emory University School of Medicine).