A novel role for proteolysis in promoting inner ear cell injury and hearing loss

蛋白水解在促进内耳细胞损伤和听力损失中的新作用

• 批准号: nhmrc : 1125376
• 负责人: Dr Justin Tan
• 金额: $ 66.42万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-role-proteolysis-hearing-loss/947563
• 关键词: novel; role; proteolysis; promoting; inner

Nearly 40% of hearing loss is attributable to traumatic noise exposure. This project will test a new idea that cells in the inner ear are damaged and die via noise-induced proteolysis, and investigate whether a similar mechanism operates during age-related hearing loss. It will open new avenues for therapies to preserve hearing where trauma is unavoidable, or has occurred through accident or incident.

近40%的听力损失可归因于创伤性噪声暴露。该项目将测试一个新的想法，即内耳细胞通过噪音诱导的蛋白水解而受损和死亡，并调查在与年龄相关的听力损失期间是否存在类似的机制。它将为治疗开辟新的途径，以保护听力创伤是不可避免的，或通过事故或事件发生。