IN-VIVO MR MICROSCOPY INSTRUMENTATION AT 11.7 TESLA

11.7 特斯拉体内 MR 显微镜仪器

• 批准号: 6288089
• 负责人: CHIEN HO
• 金额: $ 50万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-15 至 2002-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6288089
• 关键词: biomedical equipment purchase; brain imaging /visualization /scanning; heart imaging /visualization /scanning; laboratory mouse; laboratory rat; neuroimaging; nuclear magnetic resonance spectroscopy; trauma

We are requesting an 11.7-Tesla magnetic resonance (MR) instrument equipped with an 89-mm vertical bore superconducting solenoid. This instrument will allow us to carry out high-resolution in-vivo MR microscopic experiments on mice and small rats. We have assembled eight NIH-funded investigators from both Carnegie Mellon University and the University of Pittsburgh (i.e., five major and three minor users) whose research projects will greatly benefit from the availability of this high-field MR microscopic instrument. The research areas of these eight users cover a broad spectrum in biomedical sciences, e.g., brain structure and function, organ transplantation, brain tumors, head trauma, cardiology, neurology, and basement membrane. These investigators use various mouse and rat models in their research projects. The proposed MR instrument will be housed in the Pittsburgh NMR Center which was established by Carnegie Mellon University and the University of Pittsburgh as a research and training facility for applications of magnetic resonance imaging (MRI) and spectroscopy (MRS) using animal models, in particular rats and mice, to biomedical sciences. The NMR Center has the infrastructure and personnel to operate and maintain the proposed instrument. We are requesting $500,000 from the Shared Instrumentation Program as the partial cost for the proposed instrument. Carnegie Mellon University has agreed to pay the balance of the cost for an 11.7-Tesla MR instrument in excess of $500,000 and to pay the expenses needed for renovating a room located contiguous to the NMR Center to house the proposed instrument.

我们需要一台11.7特斯拉的磁共振（MR）仪器，配备一个89毫米的垂直孔超导螺线管。该仪器将使我们能够对小鼠和小大鼠进行高分辨率的体内MR显微镜实验。我们召集了来自卡内基梅隆大学和匹兹堡大学的八名NIH资助的研究人员（即，五个主要用户和三个次要用户），他们的研究项目将大大受益于这种高场MR显微仪器的可用性。这八位用户的研究领域涵盖生物医学科学的广泛领域，例如，脑结构和功能，器官移植，脑肿瘤，头部创伤，心脏病学，神经病学和基底膜。这些研究人员在他们的研究项目中使用各种小鼠和大鼠模型。拟议的磁共振仪器将被安置在匹兹堡核磁共振中心，该中心由卡内基梅隆大学和匹兹堡大学建立，作为使用动物模型（特别是大鼠和小鼠）将磁共振成像（MRI）和光谱学（MRS）应用于生物医学科学的研究和培训设施。NMR中心拥有操作和维护拟议仪器的基础设施和人员。我们要求从共享仪器计划中拨款50万美元，作为拟议仪器的部分费用。卡内基梅隆大学已同意支付超过50万美元的11.7特斯拉磁共振仪器的费用余额，并支付翻修毗邻核磁共振中心的一个房间所需的费用，以容纳拟议的仪器。