Console Electronics Upgrade for 11.7T MRI System

11.7T MRI 系统控制台电子设备升级

• 批准号: 8448370
• 负责人: CHIEN HO
• 金额: $ 56.45万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-15 至 2014-12-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8448370
• 关键词: Amplifiers; Animal Model; Area; Biomedical Research; Cardiology; Cell Nucleus; Cells; Communities; Computer software; Craniocerebral Trauma; Disabled Persons; Electronics; Equipment; Funding; Generations; Graft Rejection; Hour; Housing; Human Resources; Image; Immunology; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Manufacturer Name; Minor; Organ; Organ Transplantation; Psychiatry; Request for Applications; Research; Research Infrastructure; Research Project Grants; Running; S10 grant; Scheme; System; Technology; Tissues; United States National Institutes of Health; Universities; biomedical resource; handicapping condition; imaging modality; instrument; instrumentation; tool

DESCRIPTION (provided by applicant): In this S10 application, we are requesting funds to purchase a Bruker Avance III electronics console upgrade and accessories for an existing 11.7T/8.9cm vertical-bore micro imaging system. The existing instrument was installed in 2001 and funded in part by an NIH shared instrumentation grant (S10 RR15704). This magnet system has proved to be invaluable to the Pittsburgh NMR Center for Biomedical Research and runs over 100 hours a week. However, we now have an overwhelming and urgent need to replace the electronics console, software, and accessories because: (1) the major electronics systems, including items such as the gradient controller, RF/gradient amplifiers, digitizers, etc., are now three-generations behind current technologies. These components cannot run the most modern image acquisition schemes, and replacement parts will soon become unavailable, (2) the manufacturer (Bruker) no longer supports imaging software upgrades for our outdated console electronics. Without software upgrades, we are handicapped in our ability to apply new and emerging imaging methods that benefit our users, and (3) key hardware components have already failed, such as our X-nuclei high-power RF amplifier, or on the verge of failing, such as our gradient coil and several RF resonators. The existing 11.7T instrument is housed at the Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon University. The NMR Center has been continuously funded as a Biomedical Resource Center by the NIH (P41 EB-001977) since 1988. The NMR Center is dedicated to advancing state-of-the-art applications MRI and magnetic resonance spectroscopy (MRS) to understand tissue and organ function using animal models and making these tools available to the larger biomedical research community. The NMR Center already has in place personnel and an extensive infrastructure to operate and maintain the instrument. The availability of upgraded MRI instrumentation will serve a large number of NIH-supported research projects across diverse areas of biomedical research, including cell tracking, immunology, psychiatry, cardiology, organ transplant rejection, cancer, head trauma, and cellular therapy. Overall, the proposed equipment upgrade is critical for maintaining the 11.7T instrument as a state-of-the-art system to support ongoing research for 5 Major and 12 Minor users.

描述（由申请人提供）：在此S10申请中，我们要求资金购买Bruker Avance III电子游戏机升级和现有11.7T/8.9厘米垂直孔微观成像系统的配件。现有仪器于2001年安装，部分由NIH共享仪器赠款（S10 RR15704）资助。事实证明，这种磁铁系统对匹兹堡NMR生物医学研究中心非常宝贵，每周运行100个小时。但是，我们现在有巨大而迫切的需求来替换电子控制台，软件和配件，因为：（1）现在的主要电子系统，包括梯度控制器，RF/梯度放大器，数字化器等等项目，现在是当前技术背后的三代。这些组件无法运行最现代的图像采集方案，并且更换零件将很快变得不可用。如果没有软件升级，我们就可以使用使用户受益的新型和新兴成像方法的能力，（3）关键硬件组件已经失败，例如我们的X-Nuclei高功率RF放大器或失败的边缘，例如我们的梯度COIL COIL COIL和几个RF谐音器。现有的11.7T仪器位于卡内基·梅隆大学（Carnegie Mellon University）的匹兹堡NMR生物医学研究中心。自1988年以来，NIH（p41 EB-001977）一直将NMR中心作为生物医学资源中心持续资助。NMR中心致力于推进最先进的应用程序MRI和磁性共振光谱光谱（MRS），以便使用动物模型和为较大的生物研究群落提供这些工具，以了解组织和器官的功能。 NMR中心已经拥有现场人员和广泛的基础设施来运营和维护该工具。升级的MRI仪器的可用性将在生物医学研究的不同领域提供大量NIH支持的研究项目，包括细胞跟踪，免疫学，精神病学，心脏病学，器官移植抑制，癌症，头部创伤和细胞治疗。总体而言，拟议的设备升级对于维护11.7T仪器作为最先进的系统至关重要，以支持5个专业和12个未成年人的持续研究。