BRUKER AVANCE 4.7T NMR SPECTROMETER UPGRADE

布鲁克 AVANCE 4.7T 核磁共振波谱仪升级

• 批准号: 6288080
• 负责人: THIAN C NG
• 金额: $ 44.85万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-15 至 2005-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6288080
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; magnetic resonance imaging; nuclear magnetic resonance spectroscopy

The 4.7T/40cm NMR spectrometer at the University of Alabama at Birmingham was installed thirteen years ago. It serves an unique role in the Center for NMR Research and Development, bridging the gap between the Bruker wide-bore 360 MHz NMR spectrometer (89 mm dia bore), and the Bruker AVANCE 4.1T whole body NMR spectrometer (1m bore). The relatively high field (4.7T) wide-bore (40 cm) design makes it an ideal platform for both NMR imaging and spectroscopy experiments on phantoms and animals, and developmental work prior to implementation on the 4.1 T whole body system. The intervening decade since its installation has seen a revolution in existing NMR technology, which has rendered the existing console and supporting hardware obsolete. Due to its age, reliability and repair issues are now threatening to curtail what few capabilities the existing system does possess. We respectfully request funds to upgrade the existing 4.7T magnet to a current state-of-the-art system, which will provide high speed imaging, enhanced spectroscopic localization, and diffusion capabilities to a number of NIH-funded projects currently underway at this institution. Our current 4.7T NMR system does not possess shielded gradients, which are necessary for the reduction of eddy currents that are generated by fast imaging sequences. The reduction in noise and artifacts which accompany the addition of shielded gradients also improve both spatial and temporal resolution, and the higher gradient values and faster switching times allow implementation of sequences which are at the cutting edge of NMR research and development. We are also requesting funds for a new console to take advantage of the benefits we will see from the new gradients. Through the use of faster processors and greater programming flexibility, we will be able to implement sequences that will provide immeasurable benefit to those projects that currently use the 4.7T system to answer their research questions, and aid in the design of new strategies for future proposals.

位于伯明翰的亚拉巴马大学的4.7 T/40 cm NMR光谱仪是13年前安装的。它在核磁共振研究与开发中心发挥着独特的作用，填补了布鲁克宽口径360 MHz核磁共振波谱仪（口径89 mm）和布鲁克AVANCE 4.1 T全身核磁共振波谱仪（口径1 m）之间的差距。相对较高的场（4.7T）宽口径（40 cm）设计使其成为在体模和动物上进行NMR成像和光谱实验以及在4.1 T全身系统上实施之前进行开发工作的理想平台。自安装以来的十年见证了现有NMR技术的革命，这使得现有的控制台和支持硬件过时。由于它的年龄，可靠性和维修问题现在威胁到削减现有系统所拥有的能力。我们恭敬地请求资金将现有的4.7T磁体升级为当前最先进的系统，该系统将为该机构目前正在进行的一些NIH资助的项目提供高速成像，增强光谱定位和扩散能力。我们目前的4.7T NMR系统不具备屏蔽梯度，这是必要的减少涡流产生的快速成像序列。伴随屏蔽梯度的增加的噪声和伪影的减少也提高了空间和时间分辨率，并且更高的梯度值和更快的切换时间允许实现处于NMR研究和开发的前沿的序列。我们还要求资金用于新的控制台，以利用我们将从新梯度中看到的好处。通过使用更快的处理器和更大的编程灵活性，我们将能够实现序列，这将为那些目前使用4.7T系统回答他们的研究问题的项目提供不可估量的好处，并帮助设计未来提案的新策略。