NMR STUDIES OF HETEROGENEITY & RADIORESISTANCE OF TUMORS

体内磁共振波谱(MRS)/成像(MRI)最近 广泛应用于生理及代谢产物的研究 小鼠和人类肿瘤的改变。结果发现，31便士 和1HMRS在肿瘤膜代谢和生物能量学方面提供了信息， 有可能成为肿瘤的临床监测和/或预测指标 对治疗的反应。然而，由于环境的多样性和复杂性 肿瘤，对这些变化的认识有别于传统的肿瘤 生物化学的观点普遍很差，直接探索是 需要的。 广泛相关的生理和生化研究 肿瘤的特征及其对辐射的反应变化 提出了在原位和体外同时使用磷和氢的磁共振谱。在……里面 简介：(A)MRS观察到的代谢物和不同种类的 具有不同宿主/肿瘤细胞、Q/P细胞、 低氧组分和细胞周期时相分布将被分析和 相关；(B)亚群对本征辐射抗性的影响 将使用MRS进行检查，以阐明生物因素 引起辐射引起的代谢物改变的物质； 最终，体内MRS参数作为临床监测的意义 和/或预报器将被推导出来。

In vivo magnetic resonance spectroscopy (MRS)/imaging (MRI) has recently been extensively used in investigating the physiology and metabolite alterations of both murine and human neoplasms. It was found that the 31P and 1H MRS are informative in tumor membrane metabolism and bioenergetics, and could potentially be the clinical monitor and/or predictor of tumor response to treatments. However, due to the diversity and complexity of the tumors, the understanding of these alterations from the conventional tumor biochemistry points of view is generally poor and immediate exploration is needed. An extensive correlative study into the physiology and biochemistry of tumor characteristics and their alterations in response to irradiation using both phosphorous and hydrogen MRS in situ and vitro is proposed. In brief: (a) The variation of MRS-observed metabolites and pH of various subpopulations with different ratios of host/tumor cells, Q/P cells, hypoxic fractions, and cell cycle phase distributions will be analyzed and correlated; (b) The effects of subpopulation on intrinsic radioresistance will be examined using MRS in order to elucidate the biological factors which cause the radiation-induced alteration in the metabolites; (c) Ultimately, the significance of in vivo MRS parameters as clinical monitors and/or predictors will be deduced.