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NMR STUDIES OF HETEROGENEITY & RADIORESISTANCE OF TUMORS

异质性的核磁共振研究

基本信息

批准号：
3190745
负责人：
THIAN C NG
金额：
$ 16.21万
依托单位：
CLEVELAND CLINIC FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-04-01 至 1993-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3190745
关键词：
acidity /alkalinity bioenergetics cell membrane deuterium hypoxia laboratory mouse magnetic resonance imaging neoplasm /cancer blood supply neoplasm /cancer classification /staging neoplasm /cancer radiation therapy neoplastic cell nonhuman therapy evaluation prognosis radiation sensitivity relative biological effectiveness respiratory oxygenation squamous cell carcinoma tritium

项目摘要

In vivo magnetic resonance spectroscopy (MRS)/imaging (MRI) has recently been extensively used in investigating the physiology and metabolite alterations of both murine and human neoplasms. It was found that the 31P and 1H MRS are informative in tumor membrane metabolism and bioenergetics, and could potentially be the clinical monitor and/or predictor of tumor response to treatments. However, due to the diversity and complexity of the tumors, the understanding of these alterations from the conventional tumor biochemistry points of view is generally poor and immediate exploration is needed. An extensive correlative study into the physiology and biochemistry of tumor characteristics and their alterations in response to irradiation using both phosphorous and hydrogen MRS in situ and vitro is proposed. In brief: (a) The variation of MRS-observed metabolites and pH of various subpopulations with different ratios of host/tumor cells, Q/P cells, hypoxic fractions, and cell cycle phase distributions will be analyzed and correlated; (b) The effects of subpopulation on intrinsic radioresistance will be examined using MRS in order to elucidate the biological factors which cause the radiation-induced alteration in the metabolites; (c) Ultimately, the significance of in vivo MRS parameters as clinical monitors and/or predictors will be deduced.

最近，体内磁共振波谱（MRS）/成像（MRI）被广泛用于研究生理学和代谢物小鼠和人类肿瘤的改变。结果发现31P 1H MRS 在肿瘤膜代谢和生物能学方面提供信息，并可能成为肿瘤的临床监测和/或预测因子对治疗的反应。然而，由于事物的多样性和复杂性肿瘤，了解这些与传统肿瘤的改变生物化学观点普遍较差，立即探索是需要。对生理学和生物化学进行了广泛的相关研究肿瘤特征及其对辐射的反应变化建议在原位和体外同时使用磷和氢 MRS。在简述：(a) MRS 观察到的各种代谢物和 pH 值的变化具有不同比例的宿主/肿瘤细胞、Q/P细胞、将分析缺氧分数和细胞周期阶段分布相关； (b) 亚群对内在放射抗性的影响将使用 MRS 进行检查，以阐明生物学因素导致辐射引起的代谢物改变； (三) 最终，体内 MRS 参数作为临床监测的意义和/或预测变量将被推导出来。