DEVELOPMENT OF NEUROTRANSMITTER SYSTEMS AND BEHAVIOR

神经递质系统和行为的发展

• 批准号: 6450693
• 负责人: CHERYL F HARDING
• 金额: $ 5.95万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6450693
• 关键词: GABA receptor; behavior test; behavioral /social science research tag; catecholamine inhibitor; catecholamines; data collection methodology /evaluation; developmental neurobiology; electrochemistry; glutamate receptor; high performance liquid chromatography; male; neuroanatomy; neuroregulation; neurotransmitter metabolism; neurotransmitter receptor; sex behavior; sex differentiation; social behavior; songbirds; steroid hormone; verbal behavior; verbal learning; vocalization

The proposed research will examine whether the striking changes in catecholamine function observed during development in brain areas involved in vocal learning and/or the motor control of vocalization contribute to vocal learning and/or the differentiation and development of these brain areas. Study 1 will examine whether the use of catecholamine receptor antagonists or agonists during the period of vocal learning affects the ability to learn from a tutor, the type of receptor(s) involve, and whether drug treatment is more effective if done during the initial period of song memorization. It will also determine if such treatment causes gross changes in brain anatomy. Study 2 will investigate the effects of treating adult males with catecholamine receptor antagonists which decrease song learning to determine their immediate effects on males' singing and sexual behavior. Many of the effects of catecholamines are attributed to their effects on GABA and glutamate. Study 3 will determine whether levels and turnover of GABA and levels of glutamate change over the period of song learning and sexual differentiation of the brain areas which control singing behavior. Study 4 will examine whether early social deprivation regards the development of brain catecholamine function and levels of GABA and glutamate and whether these neurotransmitters are affected by juveniles' first interaction with a potential vocal model, suggesting an involvement in memorization of the vocal model. A major aim of this proposal is to help my colleagues in the Behavioral Neuroscience Group to meet their goals to become more productive researchers. Our formal mentoring program involves training in modern neuroscience techniques assistance in improving scientific communication skills, and specific training in writing focused grant applications. The issues addressed by this research are relevant to problems of human brain function and behavior. This research will possess possible contributions of several neurotransmitters to the development of a complex social behavior. It will also look for evidence suggesting that catecholamines are involved in stimulating some of the dramatic neuroanatomical changes which occur in brain areas controlling vocalization during the development of this behavior. Disruptions of catecholamine function have been implicated in a number of mental disorders in humans. Data providing a clearer picture of the normal involvement of brain catecholamines in the development of vocal communication in the development of vocal communication and soci8al behavior as well as the effects of experimentally induced disruptions of catecholamine function on behavior should be useful to those attempting to understand how neurotransmitter function affects behavioral and neural development.

拟议的研究将检查在发育过程中观察到的与发声学习和/或发声的运动控制有关的脑区中儿茶酚胺功能的显著变化是否有助于发声学习和/或这些脑区的分化和发育。研究1将检查在声乐学习期间使用儿茶酚胺受体拮抗剂或激动剂是否会影响从导师那里学习的能力，涉及的受体类型，以及如果在歌曲记忆的初始阶段进行药物治疗是否更有效。它还将确定这种治疗是否会导致大脑解剖结构的明显变化。研究2将研究用降低歌曲学习的儿茶酚胺受体拮抗剂治疗成年男性的效果，以确定其对男性唱歌和性行为的直接影响。 儿茶酚胺的许多作用归因于它们对GABA和谷氨酸的影响。研究3将确定在歌曲学习和控制歌唱行为的大脑区域的性别分化期间，GABA和谷氨酸水平的水平和周转率是否发生变化。研究4将探讨早期社会剥夺是否涉及脑儿茶酚胺功能和GABA和谷氨酸水平的发展，以及这些神经递质是否受到青少年与潜在声乐模型的第一次互动的影响，这表明参与声乐模型的记忆。这个提议的主要目的是帮助我在行为神经科学小组的同事们实现他们的目标，成为更有成效的研究人员。我们的正式指导计划包括现代神经科学技术的培训，帮助提高科学沟通技能，以及撰写重点资助申请的具体培训。这项研究所解决的问题与人类大脑功能和行为问题有关。这项研究将拥有几种神经递质对复杂社会行为发展的可能贡献。它还将寻找证据表明，儿茶酚胺参与刺激一些戏剧性的神经解剖学变化，这些变化发生在控制这种行为发展过程中的发声的大脑区域。儿茶酚胺功能的破坏与人类的许多精神障碍有关。这些数据提供了一个更清晰的图片，在正常情况下，大脑中的儿茶酚胺参与发展的声音沟通，在发展的声音沟通和社会行为，以及影响的实验诱导干扰的儿茶酚胺功能的行为，应该是有用的那些试图了解神经递质功能如何影响行为和神经发育。