IMMUNE RESPONSE TO LEISHMANIA MAJOR

描述(改编自申请者摘要)：以下感染 在大利什曼原虫(LM)感染的小鼠中，有Th1细胞的生长 解决感染，但Th2细胞在屈服于 疾病。本项目将测试3个主要的子假设：1)测试 假设MHC(I-A/E)和/或附件的差异表达 (ICAM)、LFA/共刺激分子(B7、CD40)及其分泌 单因子/因子对Lm特异性Th启动突触的影响 系统；2)检查APC的同源/嵌合组合和反应 T细胞，以进一步验证APC影响Th启动的假说 检验附加假设；3)监测APC分子的表达 皮损和淋巴组织中T细胞启动的重要性 引流病变的结节，并检验这一假设 影响或由APC分泌(例如，单核细胞、前列腺素E2(PGE2)) 影响Lm特异性Th启动和Lm感染的结局。

DESCRIPTION (Adapted from the Applicant's Abstract): Following infection with Leishmania major (Lm), there is outgrowth of Th1 cells in mice that resolve the infection, but outgrowth of Th2 cell in mice that succumb to disease. This project will test 3 major subhypotheses: 1) To test the hypothesis that differential expression of MHC (I-A/E) and/or accessory (ICAM), LFA/co-stimulatory molecules (B7, CD40) by APCs and the secretion of monokines/factors by A{Cs influences Lm specific Th priming syngereic system; 2) to examine congenic/chimeric combinations of APCs and responding T cells to further test the hypothesis that APCs influence Th priming and to test additional hypothesis; 3) to monitor the expression of APC molecules important to T cell priming in cutaneous lesions of Lm and in the lymph nodes draining the lesion, and to test the hypothesis that factors that influence or are secreted by APCs (e.g., monokines, prostaglandin E2 (PGE2) affect Lm specific Th priming and the outcome of infection with Lm.