CORE--ANALYTICAL

与本提案中概述的具体项目有关的环境和生物样本的毒物分析将由分析毒理学核心实验室(ATCL)进行。该设施符合美国环保局对环境毒素分析的要求，并遵循FDA所描述的良好实验室实践。此外，实验室遵循良好的QA/QC管理做法，产生高质量的分析数据，能够经受住技术同行审查的审查，并在需要时支持监管活动。该实验室目前有11名在分析药物和毒素的生物样本方面具有专业知识的工作人员，并配备了最先进的设备，包括几台GC-MS和两台LC-MS仪器。ATCL拥有专业知识和设施，可以对本提案中列出的所有毒物进行一系列矩阵的定量分析。如果个别项目需要，该设施还将提供分析方法开发和验证服务。该实验室将作为环境和健康科学之间的接口，并为研究生提供独特的培训机会。

Analysis of environmental and biological samples for toxicants associated with the specific projects outlined in this proposal will be performed by the Analytical Toxicology Core Laboratory (ATCL). This facility meets EPA requirements for the analysis of environmental toxins, as well as following Good Laboratory Practice as described by the FDA. In addition, the laboratory follows good QA/QC management practices which produce analytical data that are of high quality, that can withstand the scrutiny of technical peer review and which can support regulatory activities when needed. The laboratory presently has eleven staff with expertise in the analysis of biological samples for drugs and toxins, and is equipped with state of the art equipment including several GC-MS and two LC-MS instruments. The ATCL has the expertise and facilities to allow the quantitative analysis for all of the toxicants listed in this proposal in a range of matrices. The facility would also offer the service of analytical method development and validation should this be requirement by individual project. The laboratory will act as an interface between the environmental and health sciences and offer a unique training opportunity for graduate students.