CORE--ANALYTICAL

核心——分析

• 批准号: 6580391
• 负责人: IAN R TEBBETT
• 金额: $ 13.16万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580391
• 关键词: analytical chemistry; biomedical facility; chlorohydrocarbon; environmental toxicology; hazardous substances

Analysis of environmental and biological samples for toxicants associated with the specific projects outlined in this proposal will be performed by the Analytical Toxicology Core Laboratory (ATCL). This facility meets EPA requirements for the analysis of environmental toxins, as well as following Good Laboratory Practice as described by the FDA. In addition, the laboratory follows good QA/QC management practices which produce analytical data that are of high quality, that can withstand the scrutiny of technical peer review and which can support regulatory activities when needed. The laboratory presently has eleven staff with expertise in the analysis of biological samples for drugs and toxins, and is equipped with state of the art equipment including several GC-MS and two LC-MS instruments. The ATCL has the expertise and facilities to allow the quantitative analysis for all of the toxicants listed in this proposal in a range of matrices. The facility would also offer the service of analytical method development and validation should this be requirement by individual project. The laboratory will act as an interface between the environmental and health sciences and offer a unique training opportunity for graduate students.

分析毒理学核心实验室（ATCL）对与本提案中概述的特定项目相关的毒物的环境和生物样品进行分析。该设施符合EPA对环境毒素分析的要求，并遵循FDA所述的良好实验室实践。此外，实验室遵循良好的QA/QC管理实践，这些实践产生了高质量的分析数据，可以承受对技术同行审查的审查，并且可以在需要时支持监管活动。该实验室目前拥有11名员工，在分析药物和毒素的生物样品方面具有专业知识，并配备了最先进的设备，包括几种GC-MS和两种LC-MS仪器。 ATCL具有专业知识和设施，可以允许对本提案中在一系列矩阵中列出的所有有毒物质进行定量分析。该设施还将提供分析方法开发和验证的服务，如果个人项目需要这一要求。该实验室将充当环境和健康科学之间的界面，并为研究生提供独特的培训机会。