CORE--HUMAN GENETICS AND DATABASE

核心——人类遗传学和数据库

• 批准号: 6200885
• 负责人: JOE C CHRISTIAN
• 金额: $ 21.25万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6200885
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; alcoholism /alcohol abuse information system; behavioral /social science research tag; biomedical facility; computer data analysis; computer program /software; family genetics; genetic registry /resource /referral center; human genetic material tag; human subject; patient /disease registry; statistics /biometry; twin /multiplet

In the original application of the Indiana Alcohol Research Center (ARC) this core resource was included because of the increasing body of evidence that alcoholism and alcohol abuse have a strong genetic background. Originally this component contained ongoing alcohol challenge studies which are now part of the Human Genetics Research Component. The Human Genetics Core Resource will continue with the primary mission of providing coordination, experimental design, data storage and data analysis for human genetic ARC studies of the effects of alcohol ingestion. This model is designed to provide databases and resources that will become increasingly valuable as the years progress. Current databases collected as a result of research within the ARC include multivariate alcohol challenge data on 150 pairs of adult twins, pedigrees of 120 alcoholic probands who have multiple affected family members and DNA samples from individuals with documented responses to alcohol. A secondary mission of this core resource is to collaborate with other twin studies to further understand genetic epidemiological influences on the chronic effects of alcohol. To carry out this mission, collaborative research has been initiated with and data obtained for analysis from the National Academy of Sciences - National Research Council Twin Panel, the National Heart Lung and Blood Institute Twin Panel and the Duke University Twin Study of Memory in Aging. These resources will provide data on Caucasian male twins born between 1917 and 1927 who have had alcohol consumption data collected over the past two decades.

在印第安纳酒精研究中心（ARC）的最初应用中 包括该核心资源，因为主体的增加 证据表明酒精中毒和酗酒有很强的遗传 背景。 最初该组件含有持续的酒精 挑战研究现在是人类遗传学研究的一部分 成分。 人类遗传学核心资源将继续进行主要任务 提供协调，实验设计，数据存储和数据 人类遗传弧研究对酒精的影响的分析 摄取。 该模型旨在提供数据库和资源 随着年份的进展，这将变得越来越有价值。 当前的 由于弧内的研究而收集的数据库包括 150对成人双胞胎的多元酒精挑战数据， 有多个受影响家庭的120个酒精探险的谱系 来自有记录回答的个人的成员和DNA样本 酒精。 该核心资源的次要任务是与其他 双胞胎研究以进一步了解遗传流行病学对 酒精的慢性影响。 为执行此任务，协作 研究已开始并从中获得的数据进行分析 国家科学院 - 国家研究委员会双小组， 国家心脏肺和血液研究所双胞胎小组和公爵 大学双胞胎对衰老的记忆研究。 这些资源将提供 关于1917年至1927年之间出生的高加索男性双胞胎的数据 在过去的二十年中收集的饮酒数据。