SPECT MAMMOGRAPHY USING ROTATING SLANT HOLE COLLIMATOR

使用旋转斜孔准直器进行乳房 X 光检查

• 批准号: 6376737
• 负责人: STEPHEN B KNISLEY
• 金额: $ 23.31万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-09 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6376737
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasms; clinical research; diagnosis design /evaluation; female; human subject; mammography; neoplasm /cancer classification /staging; single photon emission computed tomography

DESCRIPTION (Adapted from Applicant's Abstract): In this application, the applicants carefully addressed the important application of the proposed SPECT technique in breast cancer staging and characterization. Preliminary results from a prototype RMSSH collimator were included. Also, a new specific aim and methods to conduct an initial clinical trial of the proposed technique were added. The innovations of the proposed SPECTM technique include: (1) the use of a MSSH collimator that provides 3 to 4 times the detection efficiency within its field-of-view than a conventional collimator with the same spatial resolution, (2) the ability to acquire complete sets of projection data by simply rotating the MSSH at 2 to 3 positions on a 90 degree arc around the breast, (3) the ability for the RMSSH collimator to stay close to the breast during data acquisition for best spatial resolution, and (4) the use of fully 3D reconstruction methods that reconstruct the complete projection data sets to provide high quality, quantitatively accurate and artifact-free reconstructed images. The research design and methods include: (1) the design of special optimized MSSH collimators for the SPECTM technique, (2) the development of transmission and emission data acquisition strategies for complete projection data sets from using the rotating MSSH collimators, (3) the development of fully 3D reconstruction methods that provide quantitatively accurate reconstructed images of the breast, (4) evaluation of the 3D SPECTM images for the detection and characterization of small and low contract breast lesions, and (5) initial pilot clinical evaluation of the SPECTM technique in five patients. The proposed new SPECTM technique can be easily implemented in most nuclear medicine clinics requiring only a low cost (about $20,000) RMSSH collimator assembly. It will provide much improved capability in evaluating the extent and characterization of breast cancers for staging purposes that have been found useful in the surgical management of breast cancer.

描述（改编自申请人摘要）：在本申请中