PKC AND TAMOXIFEN-STIMULATED TUMOR GROWTH

PKC 和他莫昔芬刺激肿瘤生长

• 批准号: 6329058
• 负责人: Debra A Tonetti
• 金额: $ 14.9万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-08 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6329058
• 关键词: antisense nucleic acid; athymic mouse; biological signal transduction; breast neoplasms; cell line; disease /disorder model; enzyme activity; estrogen receptors; gene expression; hormone related neoplasm /cancer; human tissue; isozymes; neoplasm /cancer chemotherapy; neoplasm /cancer immunotherapy; neoplastic cell; neoplastic growth; nonhuman therapy evaluation; oligonucleotides; phenotype; protein kinase C; receptor expression; tamoxifen; uterus neoplasms

项目成果

Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure.

• DOI: 10.1038/sj.bjc.6600923
• 发表时间: 2003-05-06
• 期刊: British journal of cancer
• 影响因子: 8.8

The estrogen receptor: a logical target for the prevention of breast cancer with antiestrogens.

雌激素受体：抗雌激素预防乳腺癌的合理目标。

• DOI: 10.1023/a:1018722502034
• 发表时间: 1999
• 期刊: Journal of mammary gland biology and neoplasia
• 影响因子: 2.5
• 作者: Tonetti,DA;Jordan,VC
• 通讯作者: Jordan,VC

Novel antitumor effect of estradiol in athymic mice injected with a T47D breast cancer cell line overexpressing protein kinase Calpha.

• 发表时间: 2001-10
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: M. Chisamore;Y. Ahmed;D. Bentrem;V. Jordan;D. Tonetti