REACTIVE OXYGEN SPECIES AND DROSOPHILA IMMUNITY
活性氧和果蝇免疫
基本信息
- 批准号:6386575
- 负责人:
- 金额:$ 5.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-04-01 至 2002-12-31
- 项目状态:已结题
- 来源:
- 关键词:Drosophilidae NAD(P)H dehydrogenase biological signal transduction cell cell interaction cytotoxicity electrochemistry enzyme activity fluorimetry free radical oxygen genetic strain hemolymph high performance liquid chromatography host organism interaction hydrogen peroxide hydroxyl radical immunity nitric oxide nitric oxide synthase tissue /cell culture ultraviolet spectrometry
项目摘要
DESCRIPTION (Adapted from the Applicant's Abstract): Some of the most debilitating diseases afflicting humans and other animals are either caused by insects or are vectored by them. Insect host- parasite relationships are integrating adaptations of considerable complexity. Little is known about the mechanism(s) insects use to recognize foreignness and to combat these infections. The long term goals of the proposed research are to identify the cytotoxic molecules produced by insect blood cells (hemocytes) during immune challenge, and to clarify the mechanisms by which these substances specifically target and destroy organisms that have invaded the body cavity of the host. The major focus of the proposed study concerns the involvement of hemocyte NADPH oxidase and inducible nitric oxide synthase (iNOS), since these enzymes are essential not only for the generation of cytotoxic reactive oxygen species by activated hemocytes, but also for intracellular and collaborative cell-cell signaling required for successful host encapsulation responses.
描述(改编自申请人摘要):折磨人类和其他动物的一些最使人衰弱的疾病要么是由昆虫引起的,要么是由昆虫传播的。昆虫宿主与寄生虫的关系整合了相当复杂的适应性。人们对昆虫识别外来物和对抗这些感染的机制知之甚少。本研究的长期目标是鉴定昆虫血细胞在免疫攻击过程中产生的细胞毒性分子,并阐明这些物质特异性靶向和破坏侵入宿主体腔的生物的机制。这项研究的主要焦点是血细胞NADPH氧化酶和诱导型一氧化氮合酶(iNOS)的参与,因为这些酶不仅对活化血细胞产生细胞毒性活性氧至关重要,而且对成功的宿主包封反应所需的细胞内和协同细胞-细胞信号传导也至关重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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