ATM GENE IN BREAST CANCER--PROSPECTIVE CLINICAL TRIAL
乳腺癌中的 ATM 基因——前瞻性临床试验
基本信息
- 批准号:6334987
- 负责人:
- 金额:$ 34.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-04-01 至 2001-03-31
- 项目状态:已结题
- 来源:
- 关键词:ataxia telangiectasia breast neoplasm /cancer diagnosis breast neoplasms cancer complication cancer risk clinical research clinical trials comorbidity gene expression gene mutation human subject human therapy evaluation ionizing radiation neoplasm /cancer epidemiology neoplasm /cancer genetics neoplasm /cancer surgery outcomes research polymerase chain reaction preoperative state radiation sensitivity single strand conformation polymorphism statistics /biometry
项目摘要
Ataxia telangiectasia (AT) is a multi-faceted autosomal disease in which
homozygous affected individuals have high cancer rates and extreme
radiation sensitivity. Although the AT disease is a rare entity, AT
heterozygotes may constitute an estimated 1.4% of the population, and show
a familial disposition to breast cancer. Furthermore, epidemiological
studies by Swift have suggested more than 7% of patients with breast
cancer may be heterozygotes for ATM. Patients who are heterozygotes for
ATM may be more sensitive to exposure to high doses of ionizing radiation,
constituting a subpopulation at risk for radiation complications.
Positional cloning has recently yielded the (ATM) gene sequence that is
mutated in AT patients, opening a tremendous opportunity to experimentally
address questions on the role of ATM in breast cancer epidemiology, and
its significance to diagnostic and therapeutic ionizing radiation used in
breast cancer patients.
We propose to evaluate the presence of a mutated gene (ATM) in a
prospective clinical trial of 200 patients undergoing radiation therapy to
the breast for carcinoma. We will monitor acute skin reactions, and
identify ATM mutations using RT-PCR, SSCP, PTT and sequence analysis. We
will correlate clinical observations to molecular findings to provide
evidence in support or against the hypotheses that (1) AT heterozygotes
comprise a more "radiation sensitive" cohort of patients, and (2) that
patients with breast cancer have a higher incidence of AT heterozygosity.
Furthermore, a positive correlation of ATM mutations to acute radiation
reactions will form the basis for ATM as a possible predictive assay for
breast cancer patients undergoing diagnostic and therapeutic radiation
applications.
共济失调毛细血管扩张症(AT)是一种多方面的常染色体疾病,其中
纯合子受影响的个体具有高的癌症发病率和极端的
辐射敏感性虽然AT疾病是一种罕见的实体,
杂合子可能构成估计的1.4%的人口,并显示
乳腺癌的家族遗传倾向此外,流行病学
Swift的研究表明,超过7%的乳腺癌患者
癌症可能是ATM的杂合子。杂合子患者
ATM可能对暴露于高剂量电离辐射更敏感,
构成了有辐射并发症风险的亚群。
定位克隆最近已经产生了(ATM)基因序列,
在AT患者中发生突变,为实验性地
解决ATM在乳腺癌流行病学中的作用问题,
它对诊断和治疗电离辐射的意义,
乳腺癌患者。
我们建议评估一个突变基因(ATM)的存在,
200例接受放射治疗的患者的前瞻性临床试验,
乳腺癌我们将监测急性皮肤反应,
采用RT-PCR、SSCP、PTT和序列分析鉴定ATM突变。我们
将临床观察结果与分子发现相关联,
支持或反对以下假设的证据:(1)AT杂合子
包括更“辐射敏感”的患者群,以及(2)
乳腺癌患者AT杂合性发生率较高。
此外,ATM突变与急性辐射呈正相关,
反应将形成ATM作为可能的预测分析的基础,
接受诊断和治疗放射的乳腺癌患者
应用.
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANATOLY DRITSCHILO其他文献
ANATOLY DRITSCHILO的其他文献
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{{ truncateString('ANATOLY DRITSCHILO', 18)}}的其他基金
TOPIC 345: PREDICTIVE BIOMARKERS OF PROSTATE CANCER PATIENT SENSITIVITY FOR RADIATION LATE EFFECTS
主题 345:前列腺癌患者对辐射迟发效应敏感性的预测生物标志物
- 批准号:
10029810 - 财政年份:2019
- 资助金额:
$ 34.88万 - 项目类别:
RADIOSENSITIZATION OF PANCREATIC CANCERS THROUGH RAF-1
通过 RAF-1 对胰腺癌进行放射增敏
- 批准号:
6651745 - 财政年份:2002
- 资助金额:
$ 34.88万 - 项目类别:
ATM GENE IN BREAST CANCER--PROSPECTIVE CLINICAL TRIAL
乳腺癌中的 ATM 基因——前瞻性临床试验
- 批准号:
6443863 - 财政年份:2001
- 资助金额:
$ 34.88万 - 项目类别:
MOLECULAR STUDIES OF RADIATION RESISTANT TUMOR CELLS
抗辐射肿瘤细胞的分子研究
- 批准号:
6443857 - 财政年份:2001
- 资助金额:
$ 34.88万 - 项目类别:
ATM GENE IN BREAST CANCER--PROSPECTIVE CLINICAL TRIAL
乳腺癌中的 ATM 基因——前瞻性临床试验
- 批准号:
6300543 - 财政年份:2000
- 资助金额:
$ 34.88万 - 项目类别:
MOLECULAR STUDIES OF RADIATION RESISTANT TUMOR CELLS
抗辐射肿瘤细胞的分子研究
- 批准号:
6334981 - 财政年份:2000
- 资助金额:
$ 34.88万 - 项目类别:
MOLECULAR STUDIES OF RADIATION RESISTANT TUMOR CELLS
抗辐射肿瘤细胞的分子研究
- 批准号:
6300537 - 财政年份:2000
- 资助金额:
$ 34.88万 - 项目类别:
MOLECULAR STUDIES OF RADIATION RESISTANT TUMOR CELLS
抗辐射肿瘤细胞的分子研究
- 批准号:
6103352 - 财政年份:1999
- 资助金额:
$ 34.88万 - 项目类别:
MOLECULAR STUDIES OF RADIATION RESISTANT TUMOR CELLS
抗辐射肿瘤细胞的分子研究
- 批准号:
6217501 - 财政年份:1999
- 资助金额:
$ 34.88万 - 项目类别: