Georgetown University AP4 Center Plan

描述（由申请人提供）： 乔治城大学（GU）在过去的20年里支持了一个成功的NIH/NCI资助的癌症治疗研究多学科计划，将医学肿瘤学，外科手术和放射肿瘤学整合在伦巴第综合癌症中心（LCCC）内。这项研究的一个新的方面一直集中在发展辐射增敏策略。肿瘤放射增敏（和化疗增敏）的分子靶点已被认为是药物开发研究的重要新领域，具有改善局部肿瘤控制、降低治疗相关发病率和提高治疗率的潜力。此外，工业界的兴趣集中在这类药剂的潜在市场，估计每年超过100亿美元。 在这项规划拨款申请中，机构对人员、空间和共享资源的承诺，以及两个工业合作伙伴（一家医疗器械制造商和一家生物技术公司）对财政支持的承诺，将为该计划提供最初的关键结构。在实现本申请的目标时，将确定第三方合作伙伴，计划和安排合作伙伴会议，制定战略规划、专利和出版政策。成功的竞争和完成这一规划申请的目标将允许在AP 4中心发展的下一步。

DESCRIPTION (provided by applicant): Georgetown University (GU) has supported a successful NIH/NCI funded multidisciplinary program in cancer treatment research for the past 20 years, integrating medical oncology, surgery and radiation oncology within the Lombardi Comprehensive Cancer Center (LCCC). A novel aspect of this research has been focused on developing radiation sensitizing strategies. Molecular targets for radiation sensitization (and chemosensitization) of cancers have been recognized as a significant new area for drug development research, with potential for improving local tumor control, lower treatment-related morbidities and enhanced therapeutic ratio. Furthermore, industry interest has focused on the potential market for such agents, estimated to be in excess of $10 billion annually. In this planning grant application, institutional commitment of personnel, space and shared resources, as well as commitments by two industrial partners (a medical device manufacturer and a biotechnology company) of financial support will provide the initial critical structure for this program. In the performance of the aims in this application, a third partner will be identified, a partner meeting will be planned and scheduled, strategic planning, patent and publication policies will be developed. Successful competition and completion of the aims of this planning application will allow for the next step in AP4 center development.