PEPTIDE COMBINATORIAL LIBRARY--IDENTIFY TUMOR ANTIGEN & CREATE THERAPY VACCINES

肽组合库--鉴定肿瘤抗原

• 批准号: 6300636
• 负责人: DARCY B WILSON
• 金额: $ 22.8万
• 依托单位: TORREY PINES INST FOR MOLECULAR STUDIES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-27 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6300636
• 关键词: antineoplastics; cell cycle; chemical registry /resource; cytokine; cytolysis; cytotoxic T lymphocyte; drug design /synthesis /production; enzyme linked immunosorbent assay; laboratory mouse; ovalbumin; peptide chemical synthesis; peptide library; protein sequence; tissue /cell culture; transfection; tumor antigens; vaccine development

The central goal of this program is to continue the development of an extensive collection of small molecule combinatorial libraries, and to use these libraries in cell-based screening assays for the design of new therapeutics for cancer. Four well-established senior investigators, each directing their own project, and three cores are involved in this collaborative effort. One project is directly involved in the further development of diversity in new synthetic small combinatorial libraries. A second project proposes to screen an extensive collection of peptide combinatorial libraries for molecules that trigger cytotoxic T cells and may be effective as vaccines against selected cancers. The third project will screen other small molecule, heterocycle, peptidomemetic and organic libraries for other compounds that might control abnormal cell cycle events, and similarly, the fourth project will explore libraries to identify compounds that affect various steps in the apoptosis pathway. Immune suppression, abnormal cell cycle check points, and dysregulation of normal programmed cell death mechanisms are frequently involved in the pathogenesis of tumors. Aside from an administrative core, the program also includes to specialized cores specifically designed to produce, distribute and track synthetic libraries that currently exist, as well as an additional set of diverse combinatorial biology libraries that have recently been made available Information and individual compounds resulting from these studies will provide important insights into the general problem of vaccine design based on small molecules, and in drug design for the regulation of abnormal cell division and altered events in the apoptosis pathway that are characteristic malignant cells.

该计划的中心目标是继续发展一个