QUANTITATIVE EEG IN LOW LEVEL INFORMATION PROCESSING IN LEARNING DISABILITIES

学习障碍低水平信息处理中的定量脑电图

• 批准号: 6302026
• 负责人: FRANK DUFFY
• 金额: $ 12.55万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6302026
• 关键词: association learning; auditory stimulus; behavioral /social science research tag; brain electrical activity; child psychology; clinical research; cognition disorders; developmental neurobiology; electroencephalography; evoked potentials; hearing; human subject; learning disorders; middle childhood (6-11); neural information processing; paired stimuli; perception; performance; psychomotor function; sequential perception; stimulus interval; visual pathways; visual perception; visual stimulus

The underlying hypothesis of the LDRC is that the neurodevelopmental building blocks that support low level information processing (LLIP) are specifically disordered in learning disabled (LD) children. This condition results in a deficit in the normally rapid processing of temporal information. The primary goal of Project IV is to provide, using the tools that are unique to neurophysiology, an independent validation of the hypothesized differences in LLIP between children with learning disabilities and children without such disabilities. As part of a coordinated effort with the other projects in the LDRC, Project IV will evaluate 200 LD children and 200 children in the standardization sample who, as part of Project I, will be defined and sub- grouped based on profiles of strengths and deficits on "physiological- plausible" variables of temporal information processing in the auditory, visual, and motor sequencing domains. Project IV supports the basic premise of the LDRC as stated in the Overview, namely that learning disabilities represent a functional deficit. Project IV will rely on the quantification of EEG data which is sensitive to the temporal aspects of neural function to: 1) Derive neurophysiological measures of LLIP which are sensitive to temporal information processing in visual, auditory, and motor systems domains and which characterize learning disabilities. 2) Apply a standard neurophysiological test battery which has been used to differentiate LD from normal children and to develop based upon this battery basis neurophysiologic measures of processing including cortical- cortical connectivity, spectral coherence; processing speed and efficiency, evoked potential latency; and source and number of EP generators, Brain Electrical Source Localization (BESA).

LDRC 的基本假设是神经发育 支持低级信息处理（LLIP）的构建块是 尤其是学习障碍（LD）儿童。这个条件 导致正常情况下快速处理时间的缺陷 信息。项目 IV 的主要目标是使用工具提供 这是神经生理学所独有的，是对 学习儿童之间 LLIP 的假设差异 残疾和没有这种残疾的儿童。 作为与 LDRC 其他项目协调努力的一部分， 项目 IV 将评估 200 名 LD 儿童和 200 名儿童 作为项目 I 的一部分，标准化样本将被定义并分 根据“生理- 听觉中时间信息处理的合理的“变量， 视觉和运动测序领域。项目IV支持基本 LDRC 的前提如概述中所述，即学习 残疾代表功能缺陷。项目 IV 将依赖于 脑电图数据的量化对时间方面敏感 神经功能： 1) 推导出对 LLIP 敏感的神经生理学测量 视觉、听觉和运动系统中的时间信息处理 领域和表征学习障碍的领域。 2) 使用标准的神经生理学测试电池，该电池已用于 将LD与正常儿童区分开来并以此为基础进行发展 电池基础神经生理学处理措施，包括皮质- 皮质连接性、光谱一致性；处理速度和 效率、诱发潜在潜伏期；以及EP的来源和数量 发电机、脑电源定位（BESA）。