QUANTITATIVE EEG IN LOW LEVEL INFORMATION PROCESSING IN LEARNING DISABILITIES

学习障碍低水平信息处理中的定量脑电图

• 批准号: 6272363
• 负责人: FRANK DUFFY
• 金额: $ 17.02万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6272363
• 关键词: association learning; auditory stimulus; behavioral /social science research tag; brain electrical activity; child psychology; clinical research; cognition disorders; developmental neurobiology; electroencephalography; evoked potentials; hearing; human subject; learning disorders; middle childhood (6-11); neural information processing; paired stimuli; perception; performance; psychomotor function; sequential perception; stimulus interval; visual pathways; visual perception; visual stimulus

The underlying hypothesis of the LDRC is that the neurodevelopmental building blocks that support low level information processing (LLIP) are specifically disordered in learning disabled (LD) children. This condition results in a deficit in the normally rapid processing of temporal information. The primary goal of Project IV is to provide, using the tools that are unique to neurophysiology, an independent validation of the hypothesized differences in LLIP between children with learning disabilities and children without such disabilities. As part of a coordinated effort with the other projects in the LDRC, Project IV will evaluate 200 LD children and 200 children in the standardization sample who, as part of Project I, will be defined and sub- grouped based on profiles of strengths and deficits on "physiological- plausible" variables of temporal information processing in the auditory, visual, and motor sequencing domains. Project IV supports the basic premise of the LDRC as stated in the Overview, namely that learning disabilities represent a functional deficit. Project IV will rely on the quantification of EEG data which is sensitive to the temporal aspects of neural function to: 1) Derive neurophysiological measures of LLIP which are sensitive to temporal information processing in visual, auditory, and motor systems domains and which characterize learning disabilities. 2) Apply a standard neurophysiological test battery which has been used to differentiate LD from normal children and to develop based upon this battery basis neurophysiologic measures of processing including cortical- cortical connectivity, spectral coherence; processing speed and efficiency, evoked potential latency; and source and number of EP generators, Brain Electrical Source Localization (BESA).

LDRC的基本假设是， 支持低级信息处理（LLIP）的构建块包括 特别是学习障碍（LD）儿童。这种情况 在正常情况下快速处理时间的过程中出现缺陷， 信息.项目IV的主要目标是利用工具， 这是神经生理学所独有的， 假设学习障碍儿童之间的LLIP差异 残疾儿童和无残疾儿童。 作为与地方发展研究中心其他项目协调努力的一部分， 项目IV将评估200名学习困难儿童和200名 标准化样本，作为项目I的一部分，将被定义和细分 根据“生理- 听觉中时间信息处理的“合理”变量， 视觉和马达测序领域。项目四支持基本的 正如《概览》中所述，LDRC的前提是， 残疾是一种功能缺陷。项目四将依靠 EEG数据的量化，这是敏感的时间方面， 神经功能： 1)得出LLIP的神经生理学指标，这些指标对 视觉、听觉和运动系统中的时间信息处理 领域和表征学习障碍。 2)应用标准神经生理学测试组合，该组合已用于 区分LD和正常儿童，并在此基础上发展 处理的成套神经生理学测量，包括皮质- 皮层连接性、光谱相干性、处理速度和 诱发电位潜伏期、诱发电位的来源和数目 脑电源定位（Brain Electrical Source Localization，BESA）