Sensorimotor interactions following callosotomy

胼胝体切开术后感觉运动相互作用

• 批准号: 6395994
• 负责人: MICHAEL S GAZZANIGA
• 金额: $ 17.94万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6395994
• 关键词: behavioral /social science research tag; brain interhemispheric activity; clinical research; epilepsy; evoked potentials; human subject; neural information processing; neuropsychological tests; performance; psychomotor function; sequential perception; space perception; split brain; visual stimulus

The proposed research is concerned with how people select, plan, and produce coordinated behavior. Many skilled behaviors require that the movements of the two hands be integrated in order to achieve a common goal. However, in many actions, the two hands may be engaged in essentially independent actions such as when holding a telephone with one hand and using a computer mouse with the other. Whether the hands are used to complete a common action or are engaged in different tasks, there are fundamental constraints on these movements, indicating various levels of interaction in both planning and execution stages of control. The study of split-brain patients provides a unique opportunity to study the operation of each cerebral hemisphere in relatively isolation. The proposed experiments provide a programmatic attempt to characterize the levels of representation at which integration of response components occurs. First, the temporal components of the movements are examined. Neurologically normal individuals show strong patterns of temporal coupling when producing bimanual movements. Are these phenomena observed in individuals with split-brains and if so, in a manner similar to that observe when the two hemisphere are connected? Second, the interaction of the spatial and force components of left- and right=handed movements is evaluated. Third, previous results have suggested that the existence of a shared implementation system limits performance when the two hands are used in distinct tasks. This limitation is observed even after callosotomy. A series of new experiments will rigorously assess this hypothesis. As a while, the studies should provide important insights into the psychological and neural mechanisms of coordinated behavior.

拟议的研究关注的是人们如何选择，计划和产生协调的行为。许多熟练的动作需要双手的动作相结合，以实现共同的目标。然而，在许多动作中，两只手可以参与基本上独立的动作，例如当用一只手拿着电话而用另一只手使用计算机鼠标时。无论手是用来完成一个共同的行动或从事不同的任务，有这些运动的基本约束，表明在计划和执行阶段的控制的各种层次的相互作用。对裂脑患者的研究提供了一个独特的机会，可以在相对隔离的情况下研究每个大脑半球的运作。 拟议的实验提供了一个程序化的尝试，表征水平的集成响应组件发生。首先，检查运动的时间分量。神经功能正常的个体在产生双手动作时表现出强烈的时间耦合模式。这些现象是否在裂脑个体中观察到，如果是的话，以类似于两个半球连接时观察到的方式？其次，空间和力的分量的相互作用的左，右=手的动作进行评估。第三，以前的研究结果表明，存在一个共享的执行系统限制性能时，两只手被用于不同的任务。即使在胼胝体切开术后也观察到这种限制。一系列新的实验将严格评估这一假设。同时，这些研究应该为协调行为的心理和神经机制提供重要的见解。