SLEEP DEPRIVATION, EEG, & FUNCTIONAL MRI IN DEPRESSION

描述(摘自申请者的摘要)：这五年的目标 Cametlia Clark医学博士导师临床科学家发展奖 培养应聘者在功能磁共振成像方面的专业知识 (核磁共振)，同时建立在她之前在神经成像和睡眠研究方面的技能。 这一目标将通过精心设计的培训计划来实现 包括授课课程和(加州大学圣迭戈分校内外)专家的指导 基础神经科学、结构核磁共振、功能核磁共振(FMRI)物理学、睡眠和 情感障碍的研究、统计和强化教学 在以最先进的扫描仪为特色的功能磁共振研究中， 脉冲序列(特别是灌注加权)和第一次功能磁共振研究 利用睡眠剥夺(SD)研究正常人的认知功能 (最近发表在《自然》和《神经报告》上。这项培训计划将 使克拉克博士能够完成向独立调查员的过渡 为利用功能磁共振成像和 多导睡眠图检测情感性精神障碍患者的脑功能。 研究计划使用了一晚的部分SD(PSD)，这是一种优秀的 抗抑郁治疗，见效快，不需要 药物。申请者的假设是：i)应答者的基线不佳 腹侧扣带前核(BA 25和腹侧)的灌注信号强度 24)/内侧前额叶皮质(BA 32)面积将大于 无反应者和对照组；2)PSD后，腹侧前部灌流 扣带回(BA 25和腹侧24)/内侧前额叶皮质(BA 32和10) 面积将显著减少，只有应答者。申请者还将 在其他地区寻找集团间和集团内的差异 据报道，抑郁症患者存在功能异常，包括(但不是 仅限于)背侧前扣带回、背外侧前额叶皮质、内侧 额叶皮质、杏仁核、海马体、丘脑和基底节。最后， 申请者将寻找可能的组间结构MRJ 差异，这可能会混淆功能磁共振分析。功能磁共振血流灌注 数据将通过AFNI(分析)中的方差分析算法进行分析 功能神经图像)软件。

DESCRIPTION (Adapted from applicant's abstract): The objective of this 5-year Mentored Clinical Scientist Development Award for Cametlia Clark, M.D. is to develop the candidate's expertise in functional magnetic resonance imaging (MRI) while building on her previous skills in neuroimaging and sleep research. This goal will be accomplished through a carefully designed training plan involving didactic courses and mentorship by experts (at and outside UCSD) in basic neuroscience, structural MRI, functional MRI (fMRI) physics, sleep and affective disorders research, and statistics as well as intensive instruction in fMRI research in a setting featuring state-of-the-art scanners, innovative pulse sequences (particularly perfusion-weighted), and the first fMRI studies utilizing sleep deprivation (SD) to study cognitive function in normal subjects (published recently in Nature and NeuroReport. This training program will enable Dr. Clark to complete the transition to independent investigator and provide the foundation for a long-term research program utilizing fMRI and polysomnography to investigate brain function in affective disorders. The research plan utilizes one night of partial SD (PSD), an excellent model of antidepressant treatment which is fast-acting, and does not require medications. The applicants hypothesize: I) depressed responders' baseline perfusion signal intensity in the ventral anterior cingulate (BA 25 and ventral 24) / medial prefrontal cortical (BA 32) areas will be greater than that of nonresponders and controls; 2) following PSD, perfusion in the ventral anterior cingulate (BA 25 and ventral 24) / medial prefrontal cortical (BA 32 and 10) areas will significantly decrease in responders only. The applicants will also look for between-groups and within-groups differences in other regions where functional abnormalities have been reported in depression, including (but not limited to) dorsal anterior cingulate, dorsolateral prefrontal cortices, medial frontal cortices, amygdala, hippocampus, thalamus, and basal ganglia. Finally, the applicants will look for possible between-groups structural MRJ differences, which could potentially confound fMRI analyses. FMRI perfusion data will be analyzed by the analysis of variance algorithm in AFNI (Analysis of Functional Neural Images) software.