权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

PHYSICIAN SCIENTIST TRAINING GRANT IN ONCOLOGY

肿瘤学医师科学家培训补助金

基本信息

批准号：
6375471
负责人：
CHRIS H. TAKIMOTO
金额：
$ 42.47万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
起止时间：
1992-09-05 至 2003-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6375471
关键词：
career health science research medical education oncology physicians training

项目摘要

Many institutions can train outstanding clinical oncologists, however, few institutions contain the necessary elements required to train these young clinicians for a career in investigation. San Antonio has a long history of boil basic and clinical cancer research and has developed major expertise in cooperative group trials, investigational drug development, breast cancer research, and bone marrow transplant. To obtain excellence in these areas, basic and clinical investigators have worked closely together. Recently, through the joint efforts of the University of Texas Health Science Center (UTHSCSA) and the Cancer Therapy and Research Center (CTRC), the cancer research efforts have been organized into San Antonio Cancer Institute (SACI), an NCI designated comprehensive cancer center. As described in this application, San Antonio can provide trainees with appropriate research experience, didactic instruction, and mentoring to begin a career in clinical cancer research. Our program will identify physician candidate trainees from medical, surgical, and radiation oncology. An Advisory Committee composed of key members of SACI and the clinical chairs of UTHSCSA will provide oversight for the training program. Trainees will be supported for two years on this training grant. Each trainee will select a SACI member as a mentor for their training in laboratory research skills. Once selected, Research Committee will be formed to provide detailed oversight of the trainee's progress. At the end of the first year of research support, the trainee will submit a clinical investigation proposal. The proposal will be designed to generate sufficient data to launch their research career. At the end of two years of support, th trainee will return to their clinical department as junior faculty members to continue their career development. Thus, this training program will allow young clinicians to develop an area of research expertise and bring this expertise back to their "home" clinical department.

许多机构可以培养优秀的临床肿瘤学家，然而，很少有机构具备必要的要素。培训这些年轻的临床医生，为他们的研究生涯做准备。SAN 安东尼奥有很长的基础和临床癌症病史研究并在合作小组中发展了主要专业知识试验，研究药物开发，乳腺癌研究，和骨髓移植。为了在这些领域取得卓越成绩，基础和临床研究人员密切合作。近日，通过德克萨斯大学的共同努力，健康科学中心(UTHSCSA)与癌症治疗研究在癌症研究中心(CTRC)的支持下，癌症研究工作已被组织到圣安东尼奥癌症研究所(SACI)，NCI指定的综合癌症中心。如本申请中所述，圣安东尼奥可以为学员提供适当的研究经验，说教指导和指导开始临床癌症的职业生涯研究。我们的计划将确定医生候选人实习生从内科、外科和放射肿瘤学。忠告由SACI主要成员和临床主席组成的委员会 UTHSCSA将为培训计划提供监督。实习生将用这笔培训补助金支持两年。每位实习生将选择一名SACI成员作为其培训的导师实验室研究技能。一旦入选，研究委员会将将成立，以对受训人员的进展情况进行详细监督。在第一年的研究支持结束时，实习生将提交一份临床研究建议。该提案将是旨在生成足够的数据来启动他们的研究职业生涯。在两年的支持结束后，实习生将返回作为初级教员到他们的临床科室继续他们的职业发展。因此，该培训计划将允许年轻的临床医生发展一个领域的研究专长并带来把这些专业知识带回自己的“家”临床科室。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A human breast cancer model for the study of telomerase inhibitors based on a new biotinylated-primer extension assay.

基于新的生物素化培养地扩展测定法，用于研究端粒酶抑制剂的人类乳腺癌模型。

DOI：
10.1038/sj.bjc.6690526
发表时间：
1999-07
期刊：
BRITISH JOURNAL OF CANCER
影响因子：
8.8
作者：
Raymond, E;Sun, D;Izbicka, E;Mangold, G;Silvas, E;Windle, B;Sharma, S;Soda, H;Laurence, R;Davidson, K;Von Hoff, DD
通讯作者：
Von Hoff, DD

Dimethyl sulfoxide (DMSO) causes a reversible inhibition of telomerase activity in a Burkitt lymphoma cell line.

二甲亚砜 (DMSO) 可逆性抑制伯基特淋巴瘤细胞系中的端粒酶活性。