EXTRAMURAL RES FACIL CONSTRUCTION: ALZHEIMER

外部资源设施建设：阿尔茨海默病

• 批准号: 6794470
• 负责人: JOHN C RUCKDESCHEL
• 金额: $ 15.67万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2003-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794470
• 关键词: Alzheimer's disease; animal colony; biomedical facility; building /facility design /renovation; functional /structural genomics; imaging /visualization /scanning; laboratory mouse; pathology

DESCRIPTION (provided by applicant): Support is requested to build out the 29,000 sq. ft. of uninhabitable shell space on the ground level of the new Research Building of the Moffitt Tower Project to establish a 27,683 sq. ft. Mouse Barrier Facility. Capacities of the four existing animal facilities of the centrally administered, AAALAC-accredited program in Tampa Bay, Florida have been exceeded, and all lack a secure microbiological barrier, placing studies at risk of being invalidated due to infections. The proposed facility will correct deficiencies in animal space, and establish space for functional genomic services in a setting of stringent microbiological security. It is ideally located near the greatest focus of federally-funded research involving mice, and adjacent to the area's largest concentration of research laboratory space. It will establish the following: 1) 1,956 sq. ft. of quarantine space for the unprecedented health evaluation of all mice regardless of source; 2) 6,231 sq. ft. of additional mouse housing space; 3) 2,650 sq. ft. of procedural laboratories; 4) 4,671 sq. ft. of washing and sterilizing space; 5) a dedicated laboratory for the Mouse Models Core; 6) a mouse necropsy laboratory for the Veterinary Pathology Core; and 7) a laboratory for the In Vivo Mouse Imaging Core. A 26,341 sq. ft. interstitial deck will be constructed above the facility, which will permit service access without entering the facility proper. Central Energy Plant equipment needed to meet incremental capacities demanded by the facility will be added. The net benefit of this construction project will accrue to nationally recognized life science research at eight neighboring institutions in the Tampa Bay area. Matching funds to complete the project are provided by two of those institutions.

描述（由申请人提供）：要求支持，以建立了29,000平方米。英尺在莫菲特大厦项目的新研究大楼的地面层，建立一个27，683平方米的不适合居住的外壳空间。英尺老鼠屏障设施。位于佛罗里达坦帕湾的AAALAC认证项目的集中管理的四个现有动物设施的容量已经超过，并且都缺乏安全的微生物屏障，使研究面临因感染而无效的风险。拟议的设施将纠正动物空间的缺陷，并在严格的微生物安全环境中建立功能性基因组服务空间。它位于联邦政府资助的涉及小鼠的研究的最大焦点附近，并毗邻该地区最大的研究实验室空间集中区。它将建立以下：1）1，956平方米。英尺2）6，231平方米的隔离空间，用于对所有小鼠进行前所未有的健康评估，无论其来源如何;英尺3）2，650平方米;英尺4）4，671平方米;英尺清洗和灭菌空间; 5）小鼠模型核心专用实验室; 6）兽医病理学核心小鼠尸检实验室;以及7）体内小鼠成像核心实验室。26，341平方米英尺将在设施上方建造填隙甲板，这将允许在不进入设施本身的情况下进行维修。将增加中央能源厂设备，以满足设施所需的增量容量。这个建设项目的净效益将在坦帕湾地区的八个邻近机构获得国家认可的生命科学研究。其中两个机构提供了完成该项目的配套资金。