EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION: HIV IN IN VIVO MODEL

校外研究设施建设：艾滋病毒体内模型

• 批准号: 6794467
• 负责人: JOHN C RUCKDESCHEL
• 金额: $ 3万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2003-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794467
• 关键词: animal colony; biological models; biomedical facility; building /facility design /renovation; functional /structural genomics; human immunodeficiency virus; imaging /visualization /scanning; laboratory mouse; pathology

Regarding AIDS DESCRIPTION (provided by applicant): Support is requested to build out the 29,000 sq. ft. of uninhabitable shell space on the ground level of the new Research Building of the Moffitt Tower Project to establish a 27,683 sq. ft. Mouse Barrier Facility. Capacities of the four existing animal facilities of the centrally administered, AAALAC-accredited program in Tampa Bay, Florida have been exceeded, and all lack a secure microbiological barrier, placing studies at risk of being invalidated due to infections. The proposed facility will correct deficiencies in animal space, and establish space for functional genomic services in a setting of stringent microbiological security. It is ideally located near the greatest focus of federally-funded research involving mice, and adjacent to the area's largest concentration of research laboratory space. It will establish the following: 1) 1,956 sq. ft. of quarantine space for the unprecedented health evaluation of all mice regardless of source; 2) 6,231 sq. ft. of additional mouse housing space; 3) 2,650 sq. ft. of procedural laboratories; 4) 4,671 sq. ft. of washing and sterilizing space; 5) a dedicated laboratory for the Mouse Models Core; 6) a mouse necropsy laboratory for the Veterinary Pathology Core; and 7) a laboratory for the In Vivo Mouse Imaging Core. A 26,341 sq. ft. interstitial deck will be constructed above the facility, which will permit service access without entering the facility proper. Central Energy Plant equipment needed to meet incremental capacities demanded by the facility will be added. The net benefit of this construction project will accrue to nationally recognized life science research at eight neighboring institutions in the Tampa Bay area. Matching funds to complete the project are provided by two of those institutions.

关于艾滋病描述(由申请者提供)：请求支持扩建29,000平方英尺。英国《金融时报》在莫菲特大厦项目新研究大楼的地面上建造一个不能居住的壳体空间，以建立一个27,683平方米的空间。英国《金融时报》鼠标屏障设施。位于佛罗里达州坦帕湾的中央管理的AAALAC认证计划的四个现有动物设施的能力已经超过，而且都缺乏安全的微生物屏障，使研究面临因感染而无效的风险。拟建的设施将纠正动物空间的不足，并在严格的微生物安全环境下为功能基因组服务建立空间。它的地理位置理想，靠近联邦资助的涉及老鼠的研究的最大焦点，并毗邻该地区最大的研究实验室集中地。它将建立以下设施：1)1,956平方英尺。英国《金融时报》隔离空间，用于对所有老鼠进行前所未有的健康评估，无论其来源如何；2)6,231平方英尺。英国《金融时报》增加鼠标空间；3)2,650平方英尺英国《金融时报》程序实验室；4)4671平方英尺英国《金融时报》该实验室将用于清洗和消毒空间；5)老鼠模型核心的专用实验室；6)兽医病理学核心的小鼠尸检实验室；以及7)活体小鼠成像核心的实验室。26,341平方英尺英国《金融时报》设施上方将建造间隙甲板，以便在不进入设施本身的情况下进入服务通道。将增加满足该设施所需增量能力所需的中央能源工厂设备。这个建设项目的净收益将在坦帕湾地区的八个邻近机构获得国家认可的生命科学研究。完成该项目的配套资金由其中两个机构提供。