EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION: HIV IN IN VIVO MODEL

关于艾滋病的描述（申请人提供）：要求支持建设29,000平方英尺。在莫菲特大厦项目的新研究大楼的一层建立了一个27,683平方英尺的不可居住的外壳空间。ft.老鼠屏障设施。位于佛罗里达州坦帕湾的四个经aaalac认证的中央管理的现有动物设施的能力已经超出，并且都缺乏安全的微生物屏障，使研究面临因感染而无效的风险。拟议的设施将纠正动物空间的不足，并在严格的微生物安全设置中为功能基因组服务建立空间。它理想地位于联邦资助的小鼠研究的最大焦点附近，毗邻该地区最集中的研究实验室空间。它将建立以下区域：1)1956平方公里。提供隔离空间，对所有小鼠进行史无前例的健康评估，无论来源如何；2) 6231平方米1英尺的额外老鼠窝空间；2650平方米程序实验室；4) 4671平方米4 .清洗消毒空间；5)小鼠模型核心专用实验室；6)兽医病理中心小鼠尸检实验室；7)体内小鼠成像核心实验室。面积26341平方米。将在设施上方建造一个ft间隙甲板，这将允许在不进入设施本身的情况下进行服务。将增加中央能源工厂设备，以满足该设施的增量容量需求。该建设项目的净收益将累积到坦帕湾地区八个邻近机构的国家认可的生命科学研究。其中两个机构为完成该项目提供了相应的资金。

Regarding AIDS DESCRIPTION (provided by applicant): Support is requested to build out the 29,000 sq. ft. of uninhabitable shell space on the ground level of the new Research Building of the Moffitt Tower Project to establish a 27,683 sq. ft. Mouse Barrier Facility. Capacities of the four existing animal facilities of the centrally administered, AAALAC-accredited program in Tampa Bay, Florida have been exceeded, and all lack a secure microbiological barrier, placing studies at risk of being invalidated due to infections. The proposed facility will correct deficiencies in animal space, and establish space for functional genomic services in a setting of stringent microbiological security. It is ideally located near the greatest focus of federally-funded research involving mice, and adjacent to the area's largest concentration of research laboratory space. It will establish the following: 1) 1,956 sq. ft. of quarantine space for the unprecedented health evaluation of all mice regardless of source; 2) 6,231 sq. ft. of additional mouse housing space; 3) 2,650 sq. ft. of procedural laboratories; 4) 4,671 sq. ft. of washing and sterilizing space; 5) a dedicated laboratory for the Mouse Models Core; 6) a mouse necropsy laboratory for the Veterinary Pathology Core; and 7) a laboratory for the In Vivo Mouse Imaging Core. A 26,341 sq. ft. interstitial deck will be constructed above the facility, which will permit service access without entering the facility proper. Central Energy Plant equipment needed to meet incremental capacities demanded by the facility will be added. The net benefit of this construction project will accrue to nationally recognized life science research at eight neighboring institutions in the Tampa Bay area. Matching funds to complete the project are provided by two of those institutions.