RES FACIL CONST: INFECTIOUS DIS, HSV, LEISHMANIA, PARASITE, ANIMAL MODELS

描述(由申请人提供)：UP支持向量机的生物医学研究在过去十年中翻了一番以上，自1981年以来实验室或隔膜空间没有显著增加。需要资金建造一个最先进的啮齿动物屏障设施，可容纳大约30,000只老鼠，作为一座新的教学和研究大楼的一部分。目前有四个主要的研究中心，每年从美国国立卫生研究院(NIH)获得超过1000万美元的资金。将从这个间隔库的建设中受益的中心包括传染病、比较肿瘤学、比较医学遗传学和动物转基因和生殖细胞生物学。此外，饮食行为中心还处于发展阶段。目前，支持向量机的老鼠空间不足，迫使几名研究人员将动物安置在学校外的设施中。一个新的隔室将通过以下方式纠正与支持向量机动物收容所相关的几个主要缺陷：1)整合校园内几个动物群体的小鼠收容所；2)增加可供未来生长的空间的数量和质量；3)扩大检疫设施；以及4)为小鼠群体内的调查人员提供足够的程序室。建造这个间隔室是支持向量机获得AAALAC认证计划的一部分。支持向量机致力于发展强大的动物和人类健康生物医学研究项目。研究人员在这些领域做出了科学贡献，并吸引了NIH的大量资金。现在需要资金来建造一个新的间隔室来扩大研究。

DESCRIPTION (provided by applicant): Biomedical research at the UP SVM has more than doubled over the last ten years, with no significant increase in laboratory or vivarium space since 1981. Funds are requested to build a state-of-the-art rodent barrier facility with a capacity of approximately 30,000 mice as part of a new teaching and research building. There are currently four major research centers, which obtain more than $10 million per year in National Institutes of Health (NIH) funds. The Centers that will benefit by the construction of this vivarium include Infectious Disease, Comparative Oncology, Comparative Medical Genetics, and Animal Transgenesis and Germ Cell Biology. In addition, the Center for Eating Behavior is in the development stage. Space for mice at the SVM is currently inadequate, forcing several investigators to house animals in facilities outside the School. A new vivarium will correct several major deficiencies associated with animal housing at the SVM by: 1) consolidating the housing of mice from several animal colonies across campus; 2) increasing the amount and quality of space available for future growth; 3) expanding the quarantine facilities; and 4) providing adequate procedure rooms for investigators within the mouse colony. The construction of this vivarium is part of the SVM's plan to gain AAALAC accreditation. The SVM is committed to the development of a strong biomedical research program in animal and human health. The investigators have made scientific contributions in these areas and have attracted significant NIH funds. Funds are now needed to build a new vivarium to expand research.