CORE--MORPHOLOGY/PHYSIOLOGY

形态学/生理学核心将服务于该计划的所有部分 项目核心将提供形态学、形态测量学、免疫化学 以及转基因表达模式和肌肉的功能评价， 转基因动物的神经支配反应。此外，该核心将 负责ALV载体转移到胎儿、新生儿和 成年ALV受体小鼠。将在Hughes博士实验室制备病毒贮备液 在NCI弗雷德里克，并冷冻后送往费城注射 动物对载体的结构和功能反应的评价 在受体动物中介导的基因转移也将在本研究中进行。 核心

The Morphology/Physiology Core will serve all sections of the Program Project. The Core will provide morphologic, morphometric, immunochemical and functional evaluation of transgene expression patterns and muscle and innervation responses in transgenic animals. In addition, this Core will be responsible for ALV vector transfer into muscles of fetal, neonatal and adult ALV receptor mice. Viral stocks will be prepared in Dr. Hughes lab at NCI Frederick and sent, frozen, to Philadelphia for injection into animals. Evaluation of the structural and functional response to vector mediated gene transfer in receptor animals will also be performed in this core.