CONSTRUCTION OF MAGNETIC RESONNANCE CENTER

描述(由申请人提供)：申请资金用于建造1,300平方英尺。英国《金融时报》核磁共振大楼毗邻加州大学洛杉矶分校S分子大楼一楼现有的仪器设施。这座建筑将用来容纳高场核磁共振波谱仪(600兆赫/兆赫)。现有的仪器实验室没有空间容纳600兆赫的新高场光谱仪，也没有足够的空间容纳800兆赫的光谱仪，即使目前的仪器可以搬迁。因此，这座建筑对于加州大学洛杉矶分校核磁共振设施的扩展至关重要，这是支持处于医学和生物化学前沿的生物医学研究人员所必需的。这个设施将是独一无二的，它将物理化学家、有机化学家、结构生物学家、生命科学家和医学院的教职员工聚集在一起，利用核磁共振光谱学来解决问题。将受益于核磁共振资源的具体研究领域包括蛋白质、核酸和复合体的结构生物学、大分子相互作用和动力学、结构基因组学、合成有机分子、大分子组件和天然产品的表征，以及生物分子成像。

DESCRIPTION (provided by applicant): Funds are requested for the construction of a 1,300 sq. ft. NMR building adjacent to the current instrumentation facilities on the first floor of the Molecular S Building at UCLA. This building will be used to house high field NMR spectrometers (600 MHz an MHz). There is no room in the existing instrumentation laboratories to house new high field spectrometer at 600 MHz and no adequate space to house an 800 MHz spectrometer even if current instrumentation could be relocated. Thus, this building is essential for the expansion of NMR facilities at UCLA, which is needed to support biomedical researchers at the forefront of medicine and biochemistry. This facility will be unique in bringing together physical chemists, organic chemists, structural biologists, life scientists, and faculty in the school of medicine to solve problems using NMR spectroscopy. Specific research areas that will benefit from the NMR Resource are structural biology of proteins, nucleic acids, and complexes, macromolecular interactions and dynamics, structural genomics, characterization of synthetic organic molecules, macromolecular assemblies, and natural products, and biomolecular imaging.