MUSC FACIL EXPANSION & RENOV: ORAL DIS

肌肉设施扩建

• 批准号: 6794332
• 负责人: ROSALIE K CROUCH
• 金额: $ 40万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6794332
• 关键词: animal colony; biomedical facility; building /facility design /renovation; disease /disorder model; genetically modified animals; laboratory mouse; training; university

DESCRIPTION (provided by applicant): This application requests $2 million from National Center for Research Resources (NCRR) to fit-out shell space on the seventh floor of the BSB Addition, and to upgrade sanitization and related support facilities in the existing BSB seventh floor animal facility, creating a state-of-the-art horizontally integrated rodent facility. The long-term objective is to expand MUSC's capacity for development and utilization of genetically engineered mouse models of human disease in national priority areas. Specific Aims are: 1) to provide state-of-the-art rodent facilities conducive to increasing interaction, efficiency and productivity among investigators by centralizing the program for transgenic animals; 2) to provide five new animal holding suites and a transgenic laboratory suite in an AAALAC-accreditable animal facility with BSL2 capability; and 3) to renovate the existing BSB cage wash and autoclave area. The beneficiaries are MUSC faculty members in five different basic science departments who are conducting, cutting-edge research funded by 13 different institutes of the National Institutes of Health (NIH). The grant will make it possible to facilitate recruitment of additional NIH-funded investigators who rely on animal models; remove constraints from present NIH-funded investigators who currently must design their experiments and methodology around available resources; accelerate the career development of junior investigators; improve research training opportunities for graduate students and postdoctoral fellows; make MUSC more competitive for institutional training grants by virtue of increased quality of faculty and trainees; and maintain accreditations for laboratory animal facilities. Total project cost is $4,212,617, of which the University's share is 53 percent.

描述（由申请人提供）：本申请要求国家研究资源中心（NCRR）提供200万美元，用于在BSB Addition的七楼装修外壳空间，并升级现有BSB七楼动物设施中的消毒和相关支持设施，创建最先进的水平集成啮齿动物设施。长期目标是扩大MUSC在国家优先领域开发和利用人类疾病基因工程小鼠模型的能力。具体目标是：1）通过集中转基因动物项目，提供最先进的啮齿动物设施，有助于提高研究者之间的互动、效率和生产力; 2）在具有BSL 2能力的AAALAC可识别动物设施中提供五个新的动物饲养套房和一个转基因实验室套房; 3）翻新现有的BSB笼清洗和高压灭菌区。受益者是五个不同基础科学部门的MUSC教师，他们正在进行由美国国立卫生研究院（NIH）13个不同研究所资助的尖端研究。该补助金将有助于招募更多依赖动物模型的NIH资助的研究人员;消除目前NIH资助的研究人员目前必须围绕可用资源设计实验和方法的限制;加速初级研究人员的职业发展;改善研究生和博士后研究员的研究培训机会;通过提高教师和学员的质量，使MUSC在机构培训赠款方面更具竞争力;并保持实验动物设施的认证。项目总成本为4,212,617美元，其中大学的份额为53%。