MUSC FACIL EXPANSION & RENOV: ORAL DIS

描述（由申请人提供）：本申请要求国家研究资源中心（NCRR）提供200万美元，用于装修BSB附属大楼七楼的外壳空间，并升级现有BSB七楼动物设施的卫生处理和相关支持设施，创建一个最先进的水平综合啮齿动物设施。长期目标是扩大MUSC在国家优先领域开发和利用人类疾病基因工程小鼠模型的能力。具体目标是：1)通过集中转基因动物项目，提供最先进的啮齿动物设施，有助于增加研究者之间的互动、效率和生产力；2)在具有BSL2能力的aaalac认可的动物设施中提供5个新的动物饲养套房和一个转基因实验室套房；3)改造现有的BSB笼清洗和高压灭菌区。受益者是MUSC五个不同基础科学系的教员，他们正在进行由美国国立卫生研究院（NIH） 13个不同研究所资助的尖端研究。这笔拨款将有助于招募更多依靠动物模型的nih资助的研究人员；消除目前美国国立卫生研究院资助的研究人员的限制，他们目前必须根据现有资源设计实验和方法；加快初级侦查人员的职业发展；增加研究生和博士后的科研训练机会；通过提高教师和学员的素质，使理科大学在获得机构培训补助金方面更具竞争力；并维护实验动物设施的认证。项目总成本为4,212,617美元，其中大学的份额为53%。

DESCRIPTION (provided by applicant): This application requests $2 million from National Center for Research Resources (NCRR) to fit-out shell space on the seventh floor of the BSB Addition, and to upgrade sanitization and related support facilities in the existing BSB seventh floor animal facility, creating a state-of-the-art horizontally integrated rodent facility. The long-term objective is to expand MUSC's capacity for development and utilization of genetically engineered mouse models of human disease in national priority areas. Specific Aims are: 1) to provide state-of-the-art rodent facilities conducive to increasing interaction, efficiency and productivity among investigators by centralizing the program for transgenic animals; 2) to provide five new animal holding suites and a transgenic laboratory suite in an AAALAC-accreditable animal facility with BSL2 capability; and 3) to renovate the existing BSB cage wash and autoclave area. The beneficiaries are MUSC faculty members in five different basic science departments who are conducting, cutting-edge research funded by 13 different institutes of the National Institutes of Health (NIH). The grant will make it possible to facilitate recruitment of additional NIH-funded investigators who rely on animal models; remove constraints from present NIH-funded investigators who currently must design their experiments and methodology around available resources; accelerate the career development of junior investigators; improve research training opportunities for graduate students and postdoctoral fellows; make MUSC more competitive for institutional training grants by virtue of increased quality of faculty and trainees; and maintain accreditations for laboratory animal facilities. Total project cost is $4,212,617, of which the University's share is 53 percent.