Development of a new hyphenated method for ICP-MS

开发一种新的 ICP-MS 联用方法

• 批准号: ST/V002961/1
• 负责人: Kieran Flanagan
• 金额: $ 46.61万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FV002961%2F1
• 关键词: Development; new; hyphenated; method; ICP

The aim of this project is to construct and validate a prototype that combines inductively coupled plasma mass spectrometry (ICP-MS) with the collinear resonance ionization spectroscopy (CRIS) method, developed by the University of Manchester at ISOLDE CERN. The key advantage of the CRIS technique for mass spectrometry, is its efficient removal of interference species, whether they are single ions, diatomic or polyatomic in nature. A suppression of interference species by more than 7 orders of magnitude has been demonstrated and when combined with ICP-MS will improve the limit of detection from the range of ng/g to sub pg/g universally across the periodic table. This innovation in mass spectrometry has the potential to significantly reduce the cost and time associated with the characterisation of nuclear waste. This project will focus on the challenging case of 90Sr, where the current analysis methods are slow (over 20 days lead time per sample) and expensive. As the process of decommissioning the retired UK nuclear fleet accelerates, the existing methods will not scale to meet the future demand. ICP-MS-CRIS has the potential to dramatically reduce the sample analysis time from days to minutes. This project will develop the technology by building a prototype and validating the methodology in collaboration with NPL and NNL. We will work in partnership with Dounreary Site Restoration Ltd and M2 Lasers to further develop the method and instrumentation required for a unit that can be eventually deployed in the field.

该项目的目的是构建和验证一个原型，结合电感耦合等离子体质谱（ICP-MS）与共线共振电离光谱（CRIS）方法，由曼彻斯特大学ISOLDE CERN开发。CRIS技术用于质谱分析的主要优点是其有效去除干扰物质，无论它们是单离子、双原子还是多原子。已经证明了对干扰物质的抑制超过7个数量级，并且当与ICP-MS结合时，将在整个周期表中普遍将检测限从ng/g范围提高到亚pg/g。质谱分析的这一创新有可能显著降低与核废料表征相关的成本和时间。该项目将侧重于具有挑战性的90 Sr案例，其中目前的分析方法缓慢（每个样品的交付时间超过20天）且昂贵。随着英国退役核舰队退役进程的加快，现有方法将无法满足未来的需求。ICP-MS-CRIS具有将样品分析时间从数天大幅缩短至数分钟的潜力。该项目将通过构建原型并与NPL和NNL合作验证方法来开发该技术。我们将与Dounreary Site Restoration Ltd和M2 Lasers合作，进一步开发最终可在现场部署的装置所需的方法和仪器。

项目成果

A Review of Novel Instrumentation for Matrix Independent Ultratrace Analysis of Radionuclides using Collinear Resonance Ionisation Spectroscopy (CRIS)

• DOI: 10.1051/epjconf/202226104002
• 发表时间: 2022
• 期刊: EPJ Web of Conferences
• 作者: G. Edwards;H. Perrett;Matthew P Duggan;J. Reilly;K. Flanagan