CORE--CLINICAL PHARMACOLOGY/ANALYTICAL CHEMISTRY

第一核心的目的将是提供一个集中的单位，以促进 艾滋病相关临床和基础的药理和分析研究 北卡罗来纳大学和三角研究所的科学研究。要完成 这一目标我们建议将一群公认的 分析化学的研究人员、合作者和顾问。这个 该中心向艾滋病调查员提供的服务包括： 爱滋病病毒感染者和非感染者的样本采购和处理 材料；药理学咨询及支持和支持；以及 对样品的分析。这些分析将在最先进的状态下进行 包括高性能液体的分析实验室 色谱、气相色谱、毛细管电泳核 磁共振光谱学和质谱学。实验室 将位于中心位置，并有便捷的艾滋病防治途径 北卡罗来纳州大学的调查人员。在没有拟议设施的情况下，重要的是 药物化验或其他药理学研究要么由 个人调查人员，与私人公司签约，或绕过 缺乏资金。建议的核心应满足所有分析和 艾滋病研究人员在没有不必要经济负担的情况下的药理学需求 他们的主要拨款。此外，这一设施的易用性 将刺激与艾滋病相关的新的重要药物研究。 核心潜在项目的部分清单，基于当前 北卡罗来纳大学和国际扶轮的艾滋病研究人员表达的需求包括：1.至 开发和执行准确、灵敏和具体的测量 根据非临床实验室研究的GLP标准进行，或 用于治疗逆转录病毒感染和艾滋病相关机会主义的药物 感染。化验结果将确定血液中的药物浓度， 血浆、脑脊液、精浆、尿液、呼吸液和 纸巾。2)。进行药物浓度的药代动力学分析 第一阶段/第二阶段药物开发艾滋病相关药物调查员，药物 特定患者群体中的交互协议。3)评估 测量的毛毯浓度的药效学效应。4)设计和 在患者中实施原创性药代动力学/药效学研究 感染艾滋病毒的人。5)提供分析和药代动力学支持 治疗癌症的新型前体药物的临床前代谢研究 机会性感染。

The purpose of Core I will be to provide a centralized unit to facilitate pharmacological and analytical studies of AIDS-related clinical and basic science research at UNC-CH and Research Triangle Institute. To accomplish this goal we propose to bring together a group of established investigators, collaborators, and advisors in analytical chemistry. The services provided to the AIDS investigators by the Core will include: specimen procurement and handling of HIV infected and non-infected material; pharmacology consultation and support and support; and the analysis of samples. The analyses will be conducted in a state of the art analytical laboratory that includes high performance liquid chromatography, gas chromatography, capillary electrophoresis nuclear magnetic resonance spectroscopy, and mass spectrometry. The laboratory will be centrally located and have convenient access for the AIDS investigators at UNC-CH. In the absence of the proposed facility important drug assays or other pharmacological studies were either performed by individual investigators, contracted to private firms, or bypassed for lack of funding. The proposed Core should fill all of the analytical and pharmacology needs of AIDS researchers without undue financial burden on their primary grants. In addition, the easy availability of this facility will stimulate new and important AIDS-related drug research. A partial listing of potential projects for the Core, based on current expressed needs of AIDS researchers at UNC-CH and RI, include: 1.) To develop and carry out accurate, sensitive, and specific measurements performed under GLP standards for non-clinical laboratory studies, or drugs used to treat retroviral infection and AIDS-related opportunistic infections. The assays will determine drug concentrations in blood, plasma, cerebrospinal fluid, seminal plasma, urine respiratory fluids, and tissues. 2). To perform pharmacokinetic analysis of drug concentrations in Phase I/II drug development investigators of AIDS-related agents, in drug interaction protocols in specific patient population. 3) To evaluate pharmacodynamic effects of measured rug concentrations. 4) To design and implement original pharmacokinetic/pharmacodynamic research in patients with HIV infections. 5) To provide analytic and pharmacokinetic support of preclinical metabolism studies of novel pro-drugs for treatment of opportunistic infections.