GENETIC ASSOCIATIONS OF CANNABINOID RECEPTOR ALLELES IN DRUG DEPENDEN

据报道，与大脑大麻素受体基因启动子区域中的聚A道相关的特定等位基因类型与静脉注射阿片类药物和可卡因和/或快克可卡因使用相关，但与酒精依赖无关。 这个项目的目标是提供一个独立的检查本报告使用的药物和酒精依赖的主题，我们一直在研究其他候选基因位点的集合。我们还将扩大研究范围，包括检查大麻素受体基因启动子等位基因与对cannibis的主要药物依赖之间的关联。 在过去的几个月里，我们招募了9名仅依赖大麻的受试者，最近开始分析来自450名药物和酒精依赖受试者的DNA。 迄今为止，我们的样本中没有关于研究中的大麻素标记物与物质依赖亚型之间存在关联的可报告结果。在接下来的一年里，我们预计将招募40-50名额外的大麻依赖受试者，并完成这些和我们先前确定的药物和酒精依赖受试者队列的大麻素等位基因的初始基因分型。

Specific allele types associated with poly-A tract in the promoter region of the brain cannabinoid receptor gene have been reported to be associated with intravenous opiate and cocaine and/or crack cocaine use but not with alcohol dependence. The goal of this project is to provide an independent examination of this report using a collection of drug and alcohol dependent subjects we have been studying at other candidate genetic sites. We will also extend the study to include examination of associations between alleles at the cannabinoid receptor gene promoter and primary drug dependence on cannibis. We have enrolled 9 cannabis-dependent only subjects during the last few months and have recently begun to analyze the DNA from our banked samples of 450 drug and alcohol dependent subjects at this allele. There are no reportable results to date from our sample as to the presence of associations at the cannabinoid marker under study and subtypes of substance dependence. During the next year we anticipate recruiting 40-50 additional cannabis dependent subjects and to complete the initial genotyping at the cannabinoid allele for these and our previously identified cohorts of drug and alcohol dependent subjects.