GENETIC CORRELATES OF SENSORY TRAIT MARKERS IN SCHIZOPHRENIA

这项研究调查了一系列生理特征标记的使用，而不是在这种疾病的遗传学研究中对精神分裂症本身的诊断。精神分裂症患者及其大量亲属的三项异常标记物正在调查中：听觉感觉门控、顺畅追逐和防眼跳眼球运动以及烟酸诱导的红斑。其他研究小组已经报道了这些特征与候选基因之间的关联。对同一组受试者的多个标记物的研究以前还没有报道。在本赠款年度，我们制定了在三个小时内进行这些测试和诊断性面谈的程序，使用可在临床地点之间移动的设备，以最大限度地发挥家庭招募的潜力。在过去的一年里，我们研究了55名受试者的这些特征，并证实与对照组相比，患者及其亲属的异常特征发生率升高。在接下来的一年里，我们预计将再招募和测试50-80名受试者。随着我们收集足够数量的DNA样本，我们将根据先前的文献报道，开始检查这些异常性状标记结果与特定遗传座位的关联。

This study investigates the use of a series of physiologic trait markers rather than the diagnosis of schizophrenia itself in genetic studies of this illness. Three markers which are abnormal in patients with schizophrenia and a large number of their relatives are being investigated: auditory sensory gating, smooth pursuit and anti-saccade eye movements, and niacin-induced erythema. Associations of these traits with candidate genes has been reported by other groups. Study of multiple markers for the same cohort of subjects has not been reported previously. During the current grant year we have developed procedures to carry out these tests and diagnostic interviews in a three hour period using equipment which can be moved between clinical sites to maximize family recruitment potential. During the past year we studied these traits in 55 subjects and have confirmed an elevated rate of abnormal traits in patients and their relatives as compared with controls. During the next year we anticipate recruiting and testing 50-80 additional subjects. As we collect sufficient numbers of DNA samples we will begin to examine associations of these abnormal trait marker results with specific genetic loci based on prior literature reports.