VARIABILITY IN HEPATIC IRON CONCENTRATION FROM NEEDLE BIOPSY SPECIMEN

针吸活检标本中肝铁浓度的变异性

• 批准号: 6308606
• 负责人: PAUL R HARMATZ
• 金额: $ 1.75万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308606
• 关键词: biopsy; clinical research; diagnosis quality /standard; hemoglobinopathy; human tissue; iatrogenic disease; iron poisoning; liver metabolism

Patients with sickle cell anemia or thalassemia receiving chronic transfusion therapy are at a high risk of iron overload. We would like to determine how well liver biopsy is in measuring iron overload. In this study we will use this tissue after routine testing to take additional measurements. We hope to learn how accurately iron overload is being measured by liver biopsy.

接受长期输血治疗的镰状细胞性贫血或地中海贫血患者铁过载的风险很高。 我们想确定肝脏活检在测量铁过载方面的效果。 在本研究中，我们将在常规检测后使用该组织进行额外测量。 我们希望了解通过肝活检测量铁过载的准确性。