Adiposity Related Biomarkers and Breast Tumor Size

描述(申请人的描述)越来越多的报告 证实肥胖是癌症复发和死亡的危险因素 乳腺癌患者。体重较重的女性复发风险增加或 死亡，与较瘦的女性相比，即使在控制其他预后因素后也是如此 各种因素。我们假设体重较大的女性会出现较大的 肿瘤(最终预后更差)是由以下内分泌引起的- 代谢与肥胖有关的荷尔蒙，并可能调节 乳腺肿瘤快速增殖：瘦素、1型胰岛素样生长因子 (IGF-1)、胰岛素样生长因子结合蛋白3(IGFBP-3)和 胰岛素。 胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3和胰岛素都与乳房增大有关 癌症发病率和疾病存活率下降。这些荷尔蒙是 与肥胖直接或通过中介途径相关联(例如， 生长激素/胰岛素样生长因子轴)。瘦素水平与脂肪量高度相关。 最近，两项流行病学研究发现，血液循环与 瘦素水平与乳腺癌发病率的关系。 首次发现以人群为基础的浸润性乳腺癌病例队列 通过两项关于年轻女性乳腺癌病因的大型研究，现在 对影响生存的因素的跟踪是潜在的 这个项目的基础设施。有关参与者的广泛信息已 使用详细的调查问卷收集了大量的医疗记录 回顾，以及肿瘤的组织病理学回顾和分子分析。 血浆样本是从最初研究中的参与者身上收集的， 将被用于完成感兴趣的荷尔蒙的分析。对于建议的 初步研究，将对不同组别的激素水平进行比较 青年浸润性乳腺癌中肿瘤大小和体重指数的研究 案子。荷尔蒙水平也将被检查与肿瘤的关系。 预后标记物。 迫切需要阐明潜在的生物学机制。 乳腺癌患者肥胖与预后不良相关。 这项研究的发现可能开始澄清肥胖症的机制 影响乳腺癌的预后。

DESCRIPTION (Applicant's Description) An increasing number of reports substantiate that obesity is a risk factor for recurrence and mortality in breast cancer patients. Heavier women have an increased risk of recurrence or death, compared to thinner women, even after controlling for other prognostic factors. We hypothesize that women of greater body mass present with larger tumors (and ultimately a worse prognosis) due to the following endocrine- metabolizing hormones that are associated with obesity and that may mediate rapid breast tumor proliferation: leptin, type 1 insulin-like growth factor (IGF-1), insulin-like growth factor binding protein type 3 (IGFBP-3) and insulin. IGF-1, IGFBP-3 and insulin have all been associated with both increased breast cancer incidence and decreased survival from the disease. These hormones are associated with obesity either directly or through mediating pathways (e.g., growth hormone/IGF axis). Leptin levels are highly correlated with fat mass. Recently, two epidemiologic studies found a relationship between circulating leptin levels and breast cancer incidence. A population-based cohort of invasive breast cancer cases first identified through two large studies of breast cancer etiology in young women and now being followed for factors that affect survival serves as the underlying infrastructure for this project. Extensive information on participants has been collected, using detailed questionnaires, an extensive medical records review, as well as a histopathology review and molecular analysis of tumors. Plasma samples were collected from participants in the original studies and will be used to complete assays of the hormones of interest. For the proposed pilot study, a comparison will be made of hormone levels across groups defined by tumor size and body mass index (BMI) among young invasive breast cancer cases. Hormone levels will also be examined for their relationship with tumor prognostic markers. There is a critical need to elucidate possible biologic mechanisms underlying the poor prognosis associated with obesity in breast cancer patients. Findings from this study could begin to clarify a mechanism by which adiposity affects prognosis from breast cancer.