THERAPEUTIC TARGETS TO PREVENT BREAST CANCER METASTASIS
预防乳腺癌转移的治疗目标
基本信息
- 批准号:6287275
- 负责人:
- 金额:$ 7.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-04-01 至 2003-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: (Applicant's Description) The results of our studies with
Keratinocyte Growth Factor (KGF) and the existing literature indicate that KGF
has a rapid and profound influence on breast cancer cell motility. Based on
these results, it appears that KGF, secreted from breast stromal tissue, may
act as an early signal in tumor cell proliferation and the initiation of
metastasis. If this hypothesis is correct, therapeutic inhibition of genes
and/or proteins regulated by KGF, should impede the progression of ER-positive
breast cancer cells to a metastatic phenotype and make the tumor more
manageable by surgery, endocrine therapy or other cytotoxic agents. The
central hypothesis, derived from the literature and our previous studies, is
that KGF-regulated gene products induce cell scattering motility of human
breast cancer cells, which may be an early event in the metastatic progression
of primary tumor cells. Using cDNA expression arrays, we have identified a
specific group of "Candidate Target Genes", that are up or down regulated by
KGF, which may be directly associated with KGF effects on breast cancer cells.
The hypothesis to be tested in this proposal is that specific genes, regulated
by KGF, are involved in mediating the motility of breast cancer cells.
Selective inhibition of individual candidate genes, using antisense
oligonucleotides, will be used to demonstrate the involvement of each gene
product in KGF induced motility of breast cancer cells in culture and in mouse
xenographs in vivo.
The results of this study should lead to the identification of important new
therapeutic targets and biomarkers involved in breast cancer cell progression
and metastatic development. This should result in the development of new
therapeutic agents that may be very specific and highly effective inhibitors
of breast cancer progression and metastatic spread and/or provide critical new
biomarkers for cancer staging and treatment design.
描述:(申请人的描述)我们的研究结果
角质形成细胞生长因子(KGF)及现有文献表明,KGF
对乳腺癌细胞运动具有快速而深远的影响。基于
这些结果表明,乳腺基质组织分泌的 KGF 可能
作为肿瘤细胞增殖和启动的早期信号
转移。如果这个假设是正确的,基因的治疗性抑制
和/或受 KGF 调节的蛋白质,应能阻止 ER 阳性的进展
乳腺癌细胞转化为转移表型并使肿瘤更加严重
可通过手术、内分泌治疗或其他细胞毒药物来控制。这
来自文献和我们之前的研究的中心假设是
KGF 调节的基因产物诱导人类细胞散射运动
乳腺癌细胞,这可能是转移进展的早期事件
原发性肿瘤细胞。使用 cDNA 表达阵列,我们鉴定了
特定组的“候选目标基因”,通过上调或下调
KGF,这可能与 KGF 对乳腺癌细胞的作用直接相关。
该提案要测试的假设是,受调控的特定基因
KGF 参与介导乳腺癌细胞的运动。
使用反义选择性抑制单个候选基因
寡核苷酸,将用于证明每个基因的参与
KGF 诱导培养物和小鼠乳腺癌细胞运动的产品
体内异种移植术。
这项研究的结果应该会导致重要的新发现的确定
参与乳腺癌细胞进展的治疗靶点和生物标志物
和转移发展。这应该会导致新的开发
治疗剂可能是非常特异性和高效的抑制剂
乳腺癌进展和转移扩散和/或提供重要的新信息
用于癌症分期和治疗设计的生物标志物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
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JOSEPH Thomas PENTO其他文献
JOSEPH Thomas PENTO的其他文献
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{{ truncateString('JOSEPH Thomas PENTO', 18)}}的其他基金
Selective KGFR Antagonists for the Prevention of Cancer Metastasis
选择性 KGFR 拮抗剂预防癌症转移
- 批准号:
7365010 - 财政年份:2008
- 资助金额:
$ 7.28万 - 项目类别:
THERAPEUTIC TARGETS TO PREVENT BREAST CANCER METASTASIS
预防乳腺癌转移的治疗目标
- 批准号:
6514887 - 财政年份:2001
- 资助金额:
$ 7.28万 - 项目类别:
BREAST CANCER METASTATIC POTENTIAL--ANTIESTROGEN EFFECTS
乳腺癌转移潜力——抗雌激素作用
- 批准号:
2103131 - 财政年份:1994
- 资助金额:
$ 7.28万 - 项目类别:
BREAST CANCER METASTATIC POTENTIAL--ANTIESTROGEN EFFECTS
乳腺癌转移潜力——抗雌激素作用
- 批准号:
2103130 - 财政年份:1994
- 资助金额:
$ 7.28万 - 项目类别:
BREAST CANCER METASTATIC POTENTIAL--ANTIESTROGEN EFFECTS
乳腺癌转移潜力——抗雌激素作用
- 批准号:
2103132 - 财政年份:1994
- 资助金额:
$ 7.28万 - 项目类别:
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Standard Grant