NEW METHOD FOR STUDYING DRUG SELF ADMINISTRATION IN MICE
研究小鼠自我给药的新方法
基本信息
- 批准号:6379092
- 负责人:
- 金额:$ 8.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-09-30 至 2003-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Trans-NIH Mouse Initiative is now underway for developing new,
cost-effective, high throughput phenotyping techniques to assess specific
components of central nervous system function in inbred strains of laboratory
mice. One purpose for developing such techniques is to apply this technology to
mutant mice; with the expectation that the genetic analysis of complex traits
will be facilitated and that basic brain processes and diseases of the central
nervous system will be better understood and treated. Numerous mouse knockouts
now exist, but little is known regarding the functional significance of their
altered genetics. There are many complex behaviors of interest in the Trans-NIH
Mouse Initiative; among them are cognition, learning and memory, and the taking
and seeking of drugs of abuse. The goal of this research is to develop a new
method of cocaine self-administration that can be used long-term in inbred and
genetic knockout strains of mice to simulate the full array of human behaviors
or experiences associated with drug addiction. These include the acquisition,
maintenance, extinction and reinstatement of drug-seeking and drug-taking
behavior. The present proposal seeks to develop a method of cocaine
self-administration whereby a discrete dose of aerosolized cocaine is
intermittently delivered to a sniff port after a nose-poke response, thus
avoiding many of the limitations imposed by previous methods. There are three
specific aims to accomplish this goal: (1) Design an apparatus that can
reliably deliver a discrete dose of aerosolized cocaine on an intermittent
basis; (2) Develop and validate this inhalation method of cocaine
self-administration in an inbred mouse strain by training mice to nose pole for
cocaine delivery and by varying both the dose of inhaled cocaine and the
response requirements necessary for obtaining it; (3) Apply this method in
inbred and genetic knockout strains of mice by studying the effects of nitric
oxide synthase deficiency on the acquisition, maintenance , extinction and
reinstatement of cocaine-seeking and cocaine self-administration in neuronal
NOS knockout mice and in inbred strains of mice after NOS inhibitor treatment.
跨NIH老鼠倡议目前正在进行中,目的是开发新的、
经济高效、高通量的表型分析技术,用于评估特定的
实验室近交系的中枢神经系统功能成分
老鼠。开发这种技术的一个目的是将这种技术应用于
突变小鼠;期望复杂性状的遗传分析
会被促进,大脑的基本过程和疾病的中央
神经系统将得到更好的理解和治疗。无数次的鼠标击倒
现在已经存在,但对它们的功能意义知之甚少
改变了基因。在Trans-NIH中有许多令人感兴趣的复杂行为
老鼠倡议;其中包括认知、学习和记忆,以及
以及寻求滥用药物。这项研究的目标是开发一种新的
可长期用于近交系和自交系的可卡因自我给药方法
模拟人类全部行为的小鼠基因敲除品系
或与吸毒成瘾有关的经历。其中包括收购,
维持、消灭和恢复寻找毒品和吸毒行为
行为。目前的提案试图开发一种可卡因的方法
自我给药,即离散剂量的雾化可卡因是
在鼻子戳响应之后间歇性地传送到嗅探端口,因此
避免了以前方法施加的许多限制。一共有三个
实现这一目标的具体目标:(1)设计一种能够
可靠地在间歇性地提供离散剂量的雾化可卡因
基础;(2)开发和验证这种可卡因的吸入方法
在近交系小鼠中通过训练小鼠到鼻杆进行自我给药
通过改变吸入性可卡因的剂量和
获得它所需的响应要求;(3)将此方法应用于
研究硝酸盐对近交系和基因敲除小鼠的影响
氧化合酶缺乏症的获得、维持、消退和
可卡因寻找和可卡因自我给药在神经元的恢复
一氧化氮合酶基因敲除小鼠和近交系小鼠在一氧化氮合酶抑制剂治疗后。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kathleen M. Kantak其他文献
Cocaine-cue extinction learning in rats: Impact of cocaine training dose and modulation by environmental enrichment
- DOI:
10.1016/j.drugalcdep.2015.07.1132 - 发表时间:
2015-11-01 - 期刊:
- 影响因子:
- 作者:
Jamie M. Gauthier;Roger D. Spealman;Kathleen M. Kantak - 通讯作者:
Kathleen M. Kantak
Behavioral and molecular factors contributing to beneficial effects of environmental enrichment and extinction training on cocaine relapse prevention
- DOI:
10.1016/j.drugalcdep.2014.09.249 - 发表时间:
2015-01-01 - 期刊:
- 影响因子:
- 作者:
Jamie M. Gauthier;Amy Lin;Brid A. Nic Dhonnchadha;Hengye Man;Kathleen M. Kantak - 通讯作者:
Kathleen M. Kantak
Adolescent atomoxetine, but not methylphenidate, decreases cocaine-seeking behavior in a genetic model of attention-deficit/hyperactivity disorder
- DOI:
10.1016/j.drugalcdep.2014.09.327 - 发表时间:
2015-01-01 - 期刊:
- 影响因子:
- 作者:
Chloe J. Jordan;Roxann C. Harvey;Britahny M. Baskin;Katherine Rodriguez;Angelica Dellamorte;Linda P. Dwoskin;Kathleen M. Kantak - 通讯作者:
Kathleen M. Kantak
Adolescent <span class="small-caps">d</span>-amphetamine treatment in a rodent model of ADHD: Pro-cognitive effects during adolescence and cocaine abuse risk during adulthood
- DOI:
10.1016/j.drugalcdep.2015.07.291 - 发表时间:
2015-11-01 - 期刊:
- 影响因子:
- 作者:
Chloe J. Jordan;Danielle M. Taylor;Sae-Mi Jeon;Britahny M. Baskin;Linda P. Dwoskin;Kathleen M. Kantak - 通讯作者:
Kathleen M. Kantak
Vaccines Against Drugs of Abuse
- DOI:
10.2165/00003495-200363040-00001 - 发表时间:
2003-01-01 - 期刊:
- 影响因子:14.400
- 作者:
Kathleen M. Kantak - 通讯作者:
Kathleen M. Kantak
Kathleen M. Kantak的其他文献
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{{ truncateString('Kathleen M. Kantak', 18)}}的其他基金
Nature and Predictors of Impaired Harm Avoidance in Polysubstance Abuse
多物质滥用中伤害避免受损的性质和预测因素
- 批准号:
10454265 - 财政年份:2018
- 资助金额:
$ 8.15万 - 项目类别:
Nature and Predictors of Impaired Harm Avoidance in Polysubstance Abuse
多物质滥用中伤害避免受损的性质和预测因素
- 批准号:
10651802 - 财政年份:2018
- 资助金额:
$ 8.15万 - 项目类别:
Nature and Predictors of Impaired Harm Avoidance in Polysubstance Abuse
多物质滥用中伤害避免受损的性质和预测因素
- 批准号:
10331497 - 财政年份:2018
- 资助金额:
$ 8.15万 - 项目类别:
Mechanisms of Extinction Memory Enhancement for Cocaine Addiction Treatment
可卡因成瘾治疗的消退记忆增强机制
- 批准号:
9753196 - 财政年份:2017
- 资助金额:
$ 8.15万 - 项目类别:
Mechanisms of Extinction Memory Enhancement for Cocaine Addiction Treatment
可卡因成瘾治疗的消退记忆增强机制
- 批准号:
10219214 - 财政年份:2017
- 资助金额:
$ 8.15万 - 项目类别:
Mechanisms of Extinction Memory Enhancement for Cocaine Addiction Treatment
可卡因成瘾治疗的消退记忆增强机制
- 批准号:
9440014 - 财政年份:2017
- 资助金额:
$ 8.15万 - 项目类别:
Strategies for Enhancing Extinction of Drug-Seeking Behavior
加强消除寻药行为的策略
- 批准号:
7847041 - 财政年份:2007
- 资助金额:
$ 8.15万 - 项目类别:
Strategies for Enhancing Extinction of Drug-Seeking Behavior
加强消除寻药行为的策略
- 批准号:
7679642 - 财政年份:2007
- 资助金额:
$ 8.15万 - 项目类别:
Strategies for Enhancing Extinction of Drug-Seeking Behavior
加强消除寻药行为的策略
- 批准号:
7920178 - 财政年份:2007
- 资助金额:
$ 8.15万 - 项目类别:
Strategies for Enhancing Extinction of Drug-Seeking Behavior
加强消除寻药行为的策略
- 批准号:
7497483 - 财政年份:2007
- 资助金额:
$ 8.15万 - 项目类别:
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抗可卡因(Cocaine)抗体酶的研制及实验研究
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