Source localization of auditory steady state response

听觉稳态响应的源定位

• 批准号: 6379600
• 负责人: SAMUEL D REYES
• 金额: $ 1.89万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-26 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379600
• 关键词: auditory threshold; bioimaging /biomedical imaging; brain mapping; clinical research; electroencephalography; human subject; magnetic resonance imaging; positron emission tomography; psychoacoustics; sound perception

DESCRIPTION (from applicant's abstract): The auditory steady state response (aSSR) is an electrophysiologic measure of hearing that is gaining increased clinical use as an objective measure of audiologic threshold. Recent reports also suggest dysrythmias in synchronizing activity related to aSSRs may be a common mechanism in chronic pain, Parkinson's disease, and tinnitus. However, the generators of this potential are not fully understood. A more thorough understanding of the neuroanatomy and dynamics of the SSRs will improve their diagnostic value and may lead to new treatment methods for these conditions. The goal of this study is to map the areas and sequence of activation in the brain generating aSSR. Specifically, we will: 1. Use positron emission tomography (PET) to determine the location and distribution of neural structures involved in generating the aSSR. 2. Construct dynamic maps of the location and temporal sequence of activation in the neural network generating the aSSR by combining PET and EEG source localization methods. The electrical activity of the brain during the aSSR will be recorded from the scalp in eight subjects using a 64 channel computerized EEG system. MRI from each subject will provide a detailed anatomic image, clearly segmenting skin, skull, CSF, white matter, and gray matter. The MRI image will be used to construct realistic head models for performing EEG source localization and will serve as a common anatomical space in which to compare PET and EEG data. PET data will be collected using the same stimulus used to elicit the aSSR in the EEG recordings. PET data will also be collected for a quiet resting condition. Comparing the PET data for the aSSR and baseline conditions for significant activations will allow the determination of the neural structures involved in generating the aSSR. EEG source localization constrained by the PET data will then be used to create dynamic maps of the aSSR. These dynamic maps will show the contribution of each structure and the sequence of activation involved in generating the aSSR.

描述(摘自申请者摘要)：听觉稳态反应 (ASSR)是一种正在得到提高的电生理听力测量方法 临床应用作为一种客观的听力学阈值测量方法。最近的报道 还提示与aSSR相关的同步活动中的心律失常可能是一种 慢性疼痛、帕金森氏病和耳鸣的常见机制。然而， 这种势能的产生还没有完全被理解。一个更彻底的 对SSR的神经解剖学和动力学的了解将改善他们的 具有诊断价值，并可能导致针对这些疾病的新的治疗方法。这个 这项研究的目标是绘制大脑中激活的区域和顺序 正在生成ASSR。具体地说，我们将：1.使用正电子发射断层扫描 (PET)以确定受累神经结构的位置和分布 在生成ASSR时。2.构建位置和时间的动态地图 通过组合生成ASSR的神经网络中的激活序列 PET和EEG的来源定位方法。 ASSR期间大脑的电活动将从 使用通道计算机脑电系统对8名受试者的头皮进行检测。核磁共振成像来自 每个受试者将提供详细的解剖图像，清楚地分割皮肤， 头骨、脑脊液、白质和灰质。核磁共振图像将用于 构建逼真的头部模型以执行脑电源定位和意志 作为比较PET和EEG数据的常见解剖空间。宠物 数据将使用相同的刺激来收集，用于在 脑电记录。宠物的数据也将在安静的休息条件下收集。 比较ASSR和基线条件下的PET数据 激活将允许确定所涉及的神经结构 正在生成ASSR。受PET数据约束的脑电源定位将 然后被用来创建ASSR的动态地图。这些动态地图将显示 每种结构的贡献和参与的激活序列 正在生成ASSR。